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  • Boij, RolandLinköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,County Hospital Ryhov, Sweden (author)

Regulatory T-cell Subpopulations in Severe or Early-onset Preeclampsia

  • Article/chapterEnglish2015

Publisher, publication year, extent ...

  • 2015-06-27
  • WILEY-BLACKWELL,2015
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:liu-122528
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-122528URI
  • https://doi.org/10.1111/aji.12410DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:132176267URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding Agencies|FORSS (Medical Research Council of Southeast Sweden); Futurum, academy for Health and Care Jonkoping County Council, Sweden
  • Problem A deficiency in regulatory T (Treg) cells causing reduced immune regulatory capacity has been proposed in preeclampsia. Objective Utilizing recent advances in flow cytometry phenotyping, we aimed to assess whether a deficiency of Treg subpopulations occurs in preeclampsia. Method of study Six-color flow cytometry was used for Treg phenotyping in 18 preeclamptic women (one early-onset, one severe and 16 both), 20 women with normal pregnancy, and 20 non-pregnant controls. Results No differences were found in major Treg populations including CD127(low)CD25(+)/CD127(ow)FOXP3(+), resting (FOXP3(dim)CD45RA(+)), and activated (FOXP3(bright)CD45RA(-)) Treg cells, whereas preeclamptic women showed increased CTLA-4(+) and CCR4(+) proportions within resting/activated Treg populations. Corticosteroid treatment prior to blood sampling (n = 10) affected the distribution of Treg populations. Conclusions Although we found no major alterations in circulating Treg frequencies, differences in CTLA-4(+) and CCR4(+) frequencies suggest a migratory defect of Treg cells in preeclampsia. Corticosteroid treatment should be taken into account when evaluating Treg cells.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Mjosberg, JennyKarolinska Institutet,Karolinska Institute, Sweden (author)
  • Svensson-Arvelund, Judit,1982-Linköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten(Swepub:liu)judsv82 (author)
  • Hjorth, MariaLinköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten(Swepub:liu)marhe44 (author)
  • Berg, GöranLinköpings universitet,Avdelningen för kliniska vetenskaper,Medicinska fakulteten,Region Östergötland, Kvinnokliniken US(Swepub:liu)gorbe09 (author)
  • Matthiesen, LeifLinköpings universitet,Medicinska fakulteten,Avdelningen för kliniska vetenskaper,Region Östergötland, Kvinnokliniken US,Helsingborg Hospital, Sweden(Swepub:liu)leima96 (author)
  • Jenmalm, MariaLinköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten(Swepub:liu)marje18 (author)
  • Ernerudh, JanLinköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Region Östergötland, Klinisk immunologi och transfusionsmedicin(Swepub:liu)janer15 (author)
  • Linköpings universitetAvdelningen för neuro- och inflammationsvetenskap (creator_code:org_t)

Related titles

  • In:American Journal of Reproductive Immunology: WILEY-BLACKWELL74:4, s. 368-3781046-74081600-0897

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