Can BNP-guided therapy improve health-related quality of life, and do responders to BNP-guided heart failure treatment have improved health-related quality of life? Results from the UPSTEP study.

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Karlström, PatricDepartment of Medicine, Division of Cardiology, County Hospital Ryhov, Jönköping, Sweden (författare)

Can BNP-guided therapy improve health-related quality of life, and do responders to BNP-guided heart failure treatment have improved health-related quality of life? Results from the UPSTEP study.

Artikel/kapitelEngelska2016

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2016-02-13
BioMed Central,2016
printrdacarrier

Nummerbeteckningar

LIBRIS-ID:oai:DiVA.org:liu-124558
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-124558URI
https://doi.org/10.1186/s12872-016-0221-7DOI
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-118251URI

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Språk:engelska
Sammanfattning på:engelska

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Vid tiden för disputationen förelåg publikationen endast som manuskriptFunding agencies: Swedish Heart-lung foundation [20060596]; Regional Research Foundation in south-eastern Sweden [FORSS-3963]; Regional Research Foundation in northern Sweden; Biosite international; Infiniti Medical AB
Background: To investigate whether B-type natriuretic peptide (NP)-guided treatment of heart failure (HF) patients improved their health related quality of life (Hr-QoL) compared to routine HF treatment, and whether changes in Hr-QoL differed depending on whether the patient was a responder to NP-guided therapy or not.Methods: A secondary analysis of the UPSTEP-study, a Scandinavian multicentre study using a prospective, randomized, open, blinded evaluation design on patients with HF with New York Heart Association (NYHA) class II-IV. NP-guiding was aimed to reduce BNP <150 ng/L if<75 years or BNP<300 ng/L if>75 years. A responder was defined as a patient with a BNP<300 ng/L and/or a decrease in BNP of at least 40 % in week 16 compared to study start. Short form-36 (SF-36) was used to measure Hr-QoL. At the study start, 258 patients presented evaluable SF-36 questionnaires, 131 in the BNP group and 127 in the control group. At the study end 100 patients in the NP-guided group and 98 in the control group, presenting data from both the study start and the study end.Results: There were no significant differences in Hr-QoL between NP-guided HF treatment and control group; however significant improvements could be seen in four of the eight domains in the NP-guided group, whereas in the control group improvements could be seen in six of the domains.Among the responders improvements could be noted in four domains whereas in the non-responders improvements could be seen in only one domain evaluating within group changes.Conclusions: Improved Hr-QoL could be demonstrated in several of the domains in both the NP-guided and the control group. In the responder group within group analyses showed more increased Hr-QoL compared to the non-responder group. However, all groups demonstrated increase in Hr-QoL.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kardiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cardiac and Cardiovascular Systems hsv//eng
Heart failure
treatment guided by natriuretic peptides
Health related quality of life
responders
BNP
SF-36

Biuppslag (personer, institutioner, konferenser, titlar ...)

Johansson, PeterLinköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US(Swepub:liu)petjo71 (författare)
Dahlström, UlfÖstergötlands Läns Landsting,Linköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Kardiologiska kliniken US(Swepub:liu)ulfda85 (författare)
Boman, KurtUmeå universitet,Medicin,Research unit Skellefteå Department of Medicine, Institution of Public Health and Clinical Medicine, Umeå University Sweden(Swepub:umu)kubo0001 (författare)
Alehagen, UrbanLinköpings universitet,Medicinska fakulteten,Avdelningen för kardiovaskulär medicin,Region Östergötland, Kardiologiska kliniken US(Swepub:liu)urbal84 (författare)
Department of Medicine, Division of Cardiology, County Hospital Ryhov, Jönköping, SwedenAvdelningen för kardiovaskulär medicin (creator_code:org_t)

Sammanhörande titlar

Ingår i:BMC Cardiovascular Disorders: BioMed Central161471-22611471-2261

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Av författaren/redakt...: Karlström, Patri ...; Johansson, Peter; Dahlström, Ulf; Boman, Kurt; Alehagen, Urban

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Kardiologi

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Av lärosätet: Linköpings universitet; Umeå universitet

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