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Next-Generation Seq...
Next-Generation Sequencing Reveals That HLA-DRB3, -DRB4, and -DRB5 May Be Associated With Islet Autoantibodies and Risk for Childhood Type 1 Diabetes
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- Ping Zhao, Lue (author)
- Fred Hutchinson Cancer Research Centre, WA 98104 USA
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- Alshiekh, Shehab (author)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups,Lund University, Sweden
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- Zhao, Michael (author)
- Fred Hutchinson Cancer Research Centre, WA 98104 USA
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- Carlsson, Annelie (author)
- Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University, Sweden
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- Larsson, Helena (author)
- Lund University,Lunds universitet,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Paediatric Endocrinology,Lund University Research Groups,Lund University, Sweden
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- Forsander, Gun (author)
- Sahlgrens University Hospital, Sweden
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- Ivarsson, Sten (author)
- Lund University,Lunds universitet,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Paediatric Endocrinology,Lund University Research Groups
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- Ludvigsson, Johnny (author)
- Linköping University,Linköpings universitet,Avdelningen för kliniska vetenskaper,Medicinska fakulteten,Region Östergötland, Barn- och ungdomskliniken i Linköping
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- Kockum, Ingrid (author)
- Karolinska Institutet,Karolinska Institute, Sweden
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- Marcus, Claude (author)
- Karolinska Institutet,Karolinska Institute, Sweden
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- Persson, Martina (author)
- Karolinska Institutet,Karolinska Institute, Sweden
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- Samuelsson, Ulf (author)
- Linköping University,Linköpings universitet,Avdelningen för kliniska vetenskaper,Medicinska fakulteten,Region Östergötland, Barn- och ungdomskliniken i Linköping
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- Ortqvist, Eva (author)
- Karolinska Institutet,Karolinska Institute, Sweden
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- Pyo, Chul-Woo (author)
- Fred Hutchinson Cancer Research Centre, WA 98104 USA
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- Nelson, Wyatt C. (author)
- Fred Hutchinson Cancer Research Centre, WA 98104 USA
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- Geraghty, Daniel E. (author)
- Fred Hutchinson Cancer Research Centre, WA 98104 USA
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- Lernmark, Åke (author)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups,Lund University, Sweden
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(creator_code:org_t)
- 2016-01-06
- 2016
- English.
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In: Diabetes. - : AMER DIABETES ASSOC. - 0012-1797 .- 1939-327X. ; 65:3, s. 710-718
- Related links:
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https://diabetes.dia...
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http://www.ncbi.nlm....
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.2...
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Abstract
Subject headings
Close
- The possible contribution of HLA-DRB3, -DRB4, and -DRB5 alleles to type 1 diabetes risk and to insulin autoantibody (IAA), GAD65 (GAD autoantibody [GADA]), IA-2 antigen (IA-2A), or ZnT8 against either of the three amino acid variants R, W, or Q at position 325 (ZnT8RA, ZnT8WA, and ZnT8QA, respectively) at clinical diagnosis is unclear. Next-generation sequencing (NGS) was used to determine all DRB alleles in consecutively diagnosed patients ages 1-18 years with islet autoantibody-positive type 1 diabetes (n = 970) and control subjects (n = 448). DRB3, DRB4, or DRB5 alleles were tested for an association with the risk of DRB1 for autoantibodies, type 1 diabetes, or both. The association between type 1 diabetes and DRB1*03:01:01 was affected by DRB3*01:01:02 and DRB3*02:02:01. These DRB3 alleles were associated positively with GADA but negatively with ZnT8WA, IA-2A, and IAA. The negative association between type 1 diabetes and DRB1*13:01:01 was affected by DRB3*01:01:02 to increase the risk and by DRB3*02:02:01 to maintain a negative association. DRB4*01:03:01 was strongly associated with type 1 diabetes (P = 10(-36)), yet its association was extensively affected by DRB1 alleles from protective (DRB1*04:03:01) to high (DRB1*04:01:01) risk, but its association with DRB1*04:05:01 decreased the risk. HLA-DRB3, -DRB4, and -DRB5 affect type 1 diabetes risk and islet autoantibodies. HLA typing with NGS should prove useful to select participants for prevention or intervention trials.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
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- ref (subject category)
- art (subject category)
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Diabetes
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- By the author/editor
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Ping Zhao, Lue
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Alshiekh, Shehab
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Zhao, Michael
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Carlsson, Anneli ...
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Larsson, Helena
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Forsander, Gun
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show more...
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Ivarsson, Sten
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Ludvigsson, John ...
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Kockum, Ingrid
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Marcus, Claude
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Persson, Martina
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Samuelsson, Ulf
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Ortqvist, Eva
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Pyo, Chul-Woo
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Nelson, Wyatt C.
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Geraghty, Daniel ...
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Lernmark, Åke
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
- Articles in the publication
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Diabetes
- By the university
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Linköping University
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Lund University
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Karolinska Institutet