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Structure of HDL :
Structure of HDL : particle subclasses and molecular components
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- Kontush, Anatol (författare)
- National Institute for Health and Medical Research (INSERM), UMR-ICAN 1166, Paris, France // University of Pierre and Marie Curie - Paris 6, Paris, France // Pitié – Salpétrière University Hospital, Paris, France // ICAN, Paris, France
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- Lindahl, Mats (författare)
- Linköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten
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- Lhomme, Marie (författare)
- National Institute for Health and Medical Research (INSERM), UMR-ICAN 1166, Paris, France // University of Pierre and Marie Curie - Paris 6, Paris, France // Pitié – Salpétrière University Hospital, Paris, France // ICAN, Paris, France
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- Calabresi, Laura (författare)
- Department of Pharmacological and Biomolecular Sciences, Center E. Grossi Paoletti, University of Milan, Milan, Italy
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- Chapman, M John (författare)
- National Institute for Health and Medical Research (INSERM), UMR-ICAN 1166, Paris, France // University of Pierre and Marie Curie - Paris 6, Paris, France // Pitié – Salpétrière University Hospital, Paris, France // ICAN, Paris, France
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- Davidson, W Sean (författare)
- Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, OH, 45237, USA
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(creator_code:org_t)
- 2014-12-01
- 2015
- Engelska.
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Ingår i: High Density Lipoproteins – from biological understanding to clinical exploitation. - Cham : Springer. - 9783319096643 - 9783319096650 ; , s. 3-51
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Abstract
Ämnesord
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- A molecular understanding of high-density lipoprotein (HDL) will allow a more complete grasp of its interactions with key plasma remodelling factors and with cell-surface proteins that mediate HDL assembly and clearance. However, these particles are notoriously heterogeneous in terms of almost every physical, chemical and biological property. Furthermore, HDL particles have not lent themselves to high-resolution structural study through mainstream techniques like nuclear magnetic resonance and X-ray crystallography; investigators have therefore had to use a series of lower resolution methods to derive a general structural understanding of these enigmatic particles. This chapter reviews current knowledge of the composition, structure and heterogeneity of human plasma HDL. The multifaceted composition of the HDL proteome, the multiple major protein isoforms involving translational and posttranslational modifications, the rapidly expanding knowledge of the HDL lipidome, the highly complex world of HDL subclasses and putative models of HDL particle structure are extensively discussed. A brief history of structural studies of both plasma-derived and recombinant forms of HDL is presented with a focus on detailed structural models that have been derived from a range of techniques spanning mass spectrometry to molecular dynamics.
Ämnesord
- NATURVETENSKAP -- Biologi -- Strukturbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Structural Biology (hsv//eng)
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