Sökning: WFRF:(Zanzonico P) >
Radiosynthesis of t...
-
Taldone, TonyMem Sloan Kettering Cancer Centre, NY 10065 USA
(författare)
Radiosynthesis of the iodine-124 labeled Hsp90 inhibitor PU-H71
- Artikel/kapitelEngelska2016
Förlag, utgivningsår, omfång ...
-
2016-01-25
-
WILEY-BLACKWELL,2016
-
printrdacarrier
Nummerbeteckningar
-
LIBRIS-ID:oai:DiVA.org:liu-127055
-
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-127055URI
-
https://doi.org/10.1002/jlcr.3369DOI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:ref swepub-contenttype
-
Ämneskategori:art swepub-publicationtype
Anmärkningar
-
Funding Agencies|David Rubenstein Center for Pancreatic Cancer Research; Susan G. Komen for the Cure; Department of Defense [PDF-BC093421]; MSKCC Brain Tumor Center; NIH Cancer Center Support Grant [2 P30 CA008748-48]; [P50-CA86438]; [R01 CA172546]; [R01 CA155226]; [P50 CA192937]; [R03-BC085588]
-
Heat shock protein 90 (Hsp90) is an ATP dependent molecular chaperone protein whose function is critical for maintaining several key proteins involved in survival and proliferation of cancer cells. PU-H71 (1), is a potent purine-scaffold based ATP pocket binding Hsp90 inhibitor which has been shown to have potent activity in a broad range of in vivo cancer models and is currently in Phase I clinical trials in patients with advanced solid malignancies, lymphomas, and myeloproliferative neoplasms. In this report, we describe the radiosynthesis of [I-124]-PU-H71(5); this was synthesized from the corresponding Boc-protected stannane precursor 3 by iododestannylation with [I-124]-NaI using chloramine-T as an oxidant for 2min, followed by Boc deprotection with 6 N HCl at 50 degrees C for 30min to yield the final compound. The final product 5 was purified using HPLC and was isolated with an overall yield of 55 +/- 6% (n=6, isolated) from 3, and >98% purity and an average specific activity of 980mCi/mu mol. Our report sets the stage for the introduction of [I-124]-PU-H71 as a potential non-invasive probe for understanding biodistribution and pharmacokinetics of PU-H71 in living subjects using positron emission tomography imaging.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Zatorska, DanutaMem Sloan Kettering Cancer Centre, NY 10065 USA
(författare)
-
Ochiana, Stefan O.Mem Sloan Kettering Cancer Centre, NY 10065 USA
(författare)
-
Smith-Jones, PeterMem Sloan Kettering Cancer Centre, NY 10065 USA; Stony Brook School Med, NY USA; Stony Brook School Med, NY USA
(författare)
-
Koziorowski, JacekDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York,NY, USA(Swepub:liu)jacko51
(författare)
-
Dunphy, Mark P.Mem Sloan Kettering Cancer Centre, NY 10065 USA
(författare)
-
Zanzonico, PatMem Sloan Kettering Cancer Centre, NY 10065 USA
(författare)
-
Bolaender, AlexanderMem Sloan Kettering Cancer Centre, NY 10065 USA
(författare)
-
Lewis, Jason S.Mem Sloan Kettering Cancer Centre, NY 10065 USA; Mem Sloan Kettering Cancer Centre, NY 10065 USA
(författare)
-
Larson, Steven M.Mem Sloan Kettering Cancer Centre, NY 10065 USA; Mem Sloan Kettering Cancer Centre, NY 10065 USA
(författare)
-
Chiosis, GabrielaMem Sloan Kettering Cancer Centre, NY 10065 USA
(författare)
-
Vara Kishore Pillarsetty, NagaMem Sloan Kettering Cancer Centre, NY 10065 USA
(författare)
-
Mem Sloan Kettering Cancer Centre, NY 10065 USAMem Sloan Kettering Cancer Centre, NY 10065 USA; Stony Brook School Med, NY USA; Stony Brook School Med, NY USA
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:Journal of labelled compounds & radiopharmaceuticals: WILEY-BLACKWELL59:3, s. 129-1320362-48031099-1344
Internetlänk
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Taldone, Tony
-
Zatorska, Danuta
-
Ochiana, Stefan ...
-
Smith-Jones, Pet ...
-
Koziorowski, Jac ...
-
Dunphy, Mark P.
-
visa fler...
-
Zanzonico, Pat
-
Bolaender, Alexa ...
-
Lewis, Jason S.
-
Larson, Steven M ...
-
Chiosis, Gabriel ...
-
Vara Kishore Pil ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
- Artiklar i publikationen
-
Journal of label ...
- Av lärosätet
-
Linköpings universitet