SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Zanzonico P)
 

Sökning: WFRF:(Zanzonico P) > Radiosynthesis of t...

  • Taldone, TonyMem Sloan Kettering Cancer Centre, NY 10065 USA (författare)

Radiosynthesis of the iodine-124 labeled Hsp90 inhibitor PU-H71

  • Artikel/kapitelEngelska2016

Förlag, utgivningsår, omfång ...

  • 2016-01-25
  • WILEY-BLACKWELL,2016
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:liu-127055
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-127055URI
  • https://doi.org/10.1002/jlcr.3369DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding Agencies|David Rubenstein Center for Pancreatic Cancer Research; Susan G. Komen for the Cure; Department of Defense [PDF-BC093421]; MSKCC Brain Tumor Center; NIH Cancer Center Support Grant [2 P30 CA008748-48]; [P50-CA86438]; [R01 CA172546]; [R01 CA155226]; [P50 CA192937]; [R03-BC085588]
  • Heat shock protein 90 (Hsp90) is an ATP dependent molecular chaperone protein whose function is critical for maintaining several key proteins involved in survival and proliferation of cancer cells. PU-H71 (1), is a potent purine-scaffold based ATP pocket binding Hsp90 inhibitor which has been shown to have potent activity in a broad range of in vivo cancer models and is currently in Phase I clinical trials in patients with advanced solid malignancies, lymphomas, and myeloproliferative neoplasms. In this report, we describe the radiosynthesis of [I-124]-PU-H71(5); this was synthesized from the corresponding Boc-protected stannane precursor 3 by iododestannylation with [I-124]-NaI using chloramine-T as an oxidant for 2min, followed by Boc deprotection with 6 N HCl at 50 degrees C for 30min to yield the final compound. The final product 5 was purified using HPLC and was isolated with an overall yield of 55 +/- 6% (n=6, isolated) from 3, and >98% purity and an average specific activity of 980mCi/mu mol. Our report sets the stage for the introduction of [I-124]-PU-H71 as a potential non-invasive probe for understanding biodistribution and pharmacokinetics of PU-H71 in living subjects using positron emission tomography imaging.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Zatorska, DanutaMem Sloan Kettering Cancer Centre, NY 10065 USA (författare)
  • Ochiana, Stefan O.Mem Sloan Kettering Cancer Centre, NY 10065 USA (författare)
  • Smith-Jones, PeterMem Sloan Kettering Cancer Centre, NY 10065 USA; Stony Brook School Med, NY USA; Stony Brook School Med, NY USA (författare)
  • Koziorowski, JacekDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York,NY, USA(Swepub:liu)jacko51 (författare)
  • Dunphy, Mark P.Mem Sloan Kettering Cancer Centre, NY 10065 USA (författare)
  • Zanzonico, PatMem Sloan Kettering Cancer Centre, NY 10065 USA (författare)
  • Bolaender, AlexanderMem Sloan Kettering Cancer Centre, NY 10065 USA (författare)
  • Lewis, Jason S.Mem Sloan Kettering Cancer Centre, NY 10065 USA; Mem Sloan Kettering Cancer Centre, NY 10065 USA (författare)
  • Larson, Steven M.Mem Sloan Kettering Cancer Centre, NY 10065 USA; Mem Sloan Kettering Cancer Centre, NY 10065 USA (författare)
  • Chiosis, GabrielaMem Sloan Kettering Cancer Centre, NY 10065 USA (författare)
  • Vara Kishore Pillarsetty, NagaMem Sloan Kettering Cancer Centre, NY 10065 USA (författare)
  • Mem Sloan Kettering Cancer Centre, NY 10065 USAMem Sloan Kettering Cancer Centre, NY 10065 USA; Stony Brook School Med, NY USA; Stony Brook School Med, NY USA (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Journal of labelled compounds & radiopharmaceuticals: WILEY-BLACKWELL59:3, s. 129-1320362-48031099-1344

Internetlänk

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy