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Effect of Pre-Hospi...
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Montalescot, GillesUniversity of Paris 06, France
(författare)
Effect of Pre-Hospital Ticagrelor During the First 24 h After Primary Percutaneous Coronary Intervention in Patients With ST-Segment Elevation Myocardial Infarction The ATLANTIC-H-24 Analysis
- Artikel/kapitelEngelska2016
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ELSEVIER SCIENCE INC,2016
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:liu-127552
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-127552URI
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https://doi.org/10.1016/j.jcin.2015.12.024DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Funding Agencies|AstraZeneca
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OBJECTIVES The aim of this landmark exploratory analysis, ATLANTIC-H-24, was to evaluate the effects of pre-hospital ticagrelor during the first 24 h after primary percutaneous coronary intervention (PCI) in the ATLANTIC (Administration of Ticagrelor in the cath Lab or in the Ambulance for New ST elevation myocardial infarction to open the Coronary artery) study. BACKGROUND The ATLANTIC trial in patients with ongoing ST-segment elevation myocardial infarction showed that pre-hospital ticagrelor was safe but did not improve pre-PCI coronary reperfusion compared with in-hospital ticagrelor. We hypothesized that the effect of pre-hospital ticagrelor may not have manifested until after PCI due to the rapid transfer time (31 min). METHODS The ATLANTIC-H-24 analysis included 1,629 patients who underwent PCI, evaluating platelet reactivity, Thrombolysis In Myocardial Infarction flow grade 3, >= 70% ST-segment elevation resolution, and clinical endpoints over the first 24 h. RESULTS Following PCI, largest between-group differences in platelet reactivity occurred at 1 to 6 h; coronary reperfusion rates numerically favored pre-hospital ticagrelor, and the degree of ST-segment elevation resolution was significantly greater in the pre-hospital group (median, 75.0% vs. 71.4%; p = 0.049). At 24 h, the composite ischemic endpoint was lower with pre-hospital ticagrelor (10.4% vs. 13.7%; p = 0.039), as were individual endpoints of definite stent thrombosis (p = 0.0078) and myocardial infarction (p = 0.031). All endpoints except death (1.1% vs. 0.2%; p = 0.048) favored pre-hospital ticagrelor, with no differences in bleeding events. CONCLUSIONS The effects of pre-hospital ticagrelor became apparent after PCI, with numerical differences in platelet reactivity and immediate post-PCI reperfusion, associated with reductions in ischemic endpoints, over the first 24 h, whereas there was a small excess of mortality. (Administration of Ticagrelor in the cath Lab or in the Ambulance for New ST elevation myocardial infarction to open the Coronary artery [ATLANTIC, NCT01347580]) (C) 2016 by the American College of Cardiology Foundation.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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vant Hof, Arnoud W.Isala Clin, Netherlands
(författare)
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Bolognese, LeonardoAzienda Osped Arezzo, Italy
(författare)
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Cantor, Warren J.University of Toronto, Canada
(författare)
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Cequier, AngelUniversity of Barcelona, Spain
(författare)
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Chettibi, MohamedCentre Hospital University of Frantz Fanon, Algeria
(författare)
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Collet, Jean-PhilippeUniversity of Paris 06, France
(författare)
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Goodman, Shaun G.University of Toronto, Canada
(författare)
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Hammett, Christopher J.Royal Brisbane and Womens Hospital, Australia
(författare)
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Huber, KurtWilhelminenhosp, Austria
(författare)
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Janzon, MagnusLinköpings universitet,Medicinska fakulteten,Avdelningen för kardiovaskulär medicin,Region Östergötland, Kardiologiska kliniken US(Swepub:liu)magja75
(författare)
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Lapostolle, FredericSAMU 93 Hop Avicenne, France
(författare)
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Flensted Lassen, JensAarhus University Hospital, Denmark
(författare)
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Licour, MurielAstraZeneca, France
(författare)
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Merkely, BelaSemmelweis University, Hungary
(författare)
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Salhi, NejouaAstraZeneca, England
(författare)
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Silvain, JohanneUniversity of Paris 06, France
(författare)
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Storey, Robert F.University of Sheffield, England
(författare)
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ten Berg, Jurrien M.St Antonius Hospital, Netherlands
(författare)
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Tsatsaris, AnneAstraZeneca, France
(författare)
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Zeymer, UweKlinikum Ludwigshafen, Germany; Institute Herzinfarktforsch Ludwigshafen, Germany
(författare)
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Vicaut, EricUniversity of Paris 07, France
(författare)
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Hamm, Christian W.Kerckhoff Heart Centre, Germany
(författare)
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University of Paris 06, FranceIsala Clin, Netherlands
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:JACC: ELSEVIER SCIENCE INC9:7, s. 646-6561936-87981876-7605
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vant Hof, Arnoud ...
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Bolognese, Leona ...
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Cantor, Warren J ...
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Cequier, Angel
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Chettibi, Mohame ...
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Collet, Jean-Phi ...
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Goodman, Shaun G ...
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Huber, Kurt
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Flensted Lassen, ...
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Licour, Muriel
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Merkely, Bela
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Salhi, Nejoua
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Silvain, Johanne
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Storey, Robert F ...
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Tsatsaris, Anne
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Zeymer, Uwe
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