Sökning: WFRF:(Omda R) >
X Chromosome Dose a...
-
Liu, KeUniversity of Cincinnati, OH USA; Cincinnati Childrens Hospital Medical Centre, OH 45229 USA
(författare)
X Chromosome Dose and Sex Bias in Autoimmune Diseases
- Artikel/kapitelEngelska2016
Förlag, utgivningsår, omfång ...
-
WILEY-BLACKWELL,2016
-
printrdacarrier
Nummerbeteckningar
-
LIBRIS-ID:oai:DiVA.org:liu-128940
-
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-128940URI
-
https://doi.org/10.1002/art.39560DOI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:ref swepub-contenttype
-
Ämneskategori:art swepub-publicationtype
Anmärkningar
-
Funding Agencies|NIH [AR-062755, AI-024717, AI-031584, AI-062629, AI-063274, AI-082714, AI-083194, AI-101934]; NIH (National Institute of Dental and Craniofacial Research Intramural Research Program); University of Oklahoma Health Sciences Center (Clinical and Translational Science OCTSI Summer Scholar Program); US Department of Veterans Affairs [IMMA9]; US Department of Defense [PR094002]; Alliance for Lupus Research; Kirkland Scholar Program; Strategic Research Program at Helse Bergen; Western Norway Regional Health Authority; Broegelmann Foundation; French Ministry of Health (EvASSESS Programme Hospitalier de Recherche Clinique); Swedish Rheumatism Foundation; Arthritis Australia; Research to Prevent Blindness; Medical Research Council, UK [G0800629]; DFG [KFO 250 WI 1031/6-1]; Canadian Institutes of Health Research [MOP89955, MOP74621]; Ontario Research Fund [RE05-075]; Canada Research Chair Program; Instituto de Salud Carlos III (ISCIII through FEDER) [02558]; Allergan; Lilly; UCB; The NIH [AR-042460, AR-048204, AR-048940, AR-049084, AR-052125, AR-053483, AR-053734, AR-056360, AR-058959, AR-062277, AR-043814, AR-065626, DE-015223, DE-018209, RR-020143, GM-103510, GM-104938, HG-008667, TR-001475, HG-006828]
-
Objective. More than 80% of autoimmune disease predominantly affects females, but the mechanism for this female bias is poorly understood. We suspected that an X chromosome dose effect accounts for this, and we undertook this study to test our hypothesis that trisomy X (47, XXX; occurring in similar to 1 in 1,000 live female births) would be increased in patients with female-predominant diseases (systemic lupus erythematosus [SLE], primary Sjogrens syndrome [SS], primary biliary cirrhosis, and rheumatoid arthritis [RA]) compared to patients with diseases without female predominance (sarcoidosis) and compared to controls. Methods. All subjects in this study were female. We identified subjects with 47, XXX using aggregate data from single-nucleotide polymorphism arrays, and, when possible, we confirmed the presence of 47, XXX using fluorescence in situ hybridization or quantitative polymerase chain reaction. Results. We found 47, XXX in 7 of 2,826 SLE patients and in 3 of 1,033 SS patients, but in only 2 of 7,074 controls (odds ratio in the SLE and primary SS groups 8.78 [95% confidence interval 1.67-86.79], P = 0.003 and odds ratio 10.29 [95% confidence interval 1.18-123.47], P = 0.02, respectively). One in 404 women with SLE and 1 in 344 women with SS had 47, XXX. There was an excess of 47, XXX among SLE and SS patients. Conclusion. The estimated prevalence of SLE and SS in women with 47, XXX was similar to 2.5 and similar to 2.9 times higher, respectively, than that in women with 46, XX and similar to 25 and similar to 41 times higher, respectively, than that in men with 46, XY. No statistically significant increase of 47, XXX was observed in other female-biased diseases (primary biliary cirrhosis or RA), supporting the idea of multiple pathways to sex bias in autoimmunity.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Kurien, Biji T.University of Oklahoma, OK 73190 USA; Oklahoma City VA Medical Centre, OK USA
(författare)
-
Zimmerman, Sarah L.Cincinnati Childrens Hospital Medical Centre, OH 45229 USA
(författare)
-
Kaufman, Kenneth M.Cincinnati Childrens Hospital Medical Centre, OH 45229 USA; Cincinnati VA Medical Centre, OH USA
(författare)
-
Taft, Diana H.Cincinnati Childrens Hospital Medical Centre, OH 45229 USA
(författare)
-
Kottyan, Leah C.Cincinnati Childrens Hospital Medical Centre, OH 45229 USA
(författare)
-
Lazaro, SaraCincinnati Childrens Hospital Medical Centre, OH 45229 USA
(författare)
-
Weaver, Carrie A.Cincinnati Childrens Hospital Medical Centre, OH 45229 USA
(författare)
-
Ice, John A.Oklahoma Medical Research Fdn, OK 73104 USA
(författare)
-
Adler, Adam J.Oklahoma City VA Medical Centre, OK USA; Oklahoma Medical Research Fdn, OK 73104 USA
(författare)
-
Chodosh, JamesMassachusetts Eye and Ear Infirm, MA 02114 USA; Harvard University, MA USA
(författare)
-
Radfar, LidaUniversity of Oklahoma, OK USA; University of Oklahoma, OK USA
(författare)
-
Rasmussen, AstridOklahoma Medical Research Fdn, OK 73104 USA
(författare)
-
Stone, Donald U.University of Oklahoma, OK USA; University of Oklahoma, OK 73190 USA
(författare)
-
Lewis, David M.University of Oklahoma, OK USA; University of Oklahoma, OK USA
(författare)
-
Li, ShiboUniversity of Oklahoma, OK USA; University of Oklahoma, OK 73190 USA
(författare)
-
Koelsch, Kristi A.Oklahoma Medical Research Fdn, OK 73104 USA
(författare)
-
Igoe, AnnOklahoma Medical Research Fdn, OK 73104 USA
(författare)
-
Talsania, MitaliUniversity of Oklahoma, OK USA; University of Oklahoma, OK 73190 USA
(författare)
-
Kumar, JayOklahoma Medical Research Fdn, OK 73104 USA
(författare)
-
Maier-Moore, Jacen S.University of Oklahoma, OK 73190 USA; Oklahoma City VA Medical Centre, OK USA; University of Texas El Paso, TX 79968 USA
(författare)
-
Harris, Valerie M.Oklahoma Medical Research Fdn, OK 73104 USA
(författare)
-
Gopalakrishnan, RajaramUniversity of Minnesota, MN USA
(författare)
-
Jonsson, RolandUniversity of Bergen, Norway; Haukeland Hospital, Norway
(författare)
-
Lessard, James A.Valley Bone and Joint Clin, ND USA
(författare)
-
Lu, XianglanUniversity of Oklahoma, OK USA; University of Oklahoma, OK 73190 USA
(författare)
-
-Eric Gottenberg, JacquesStrasbourg University, France
(författare)
-
-Manuel Anaya, JuanUniversity of Rosario, Colombia
(författare)
-
Cunninghame-Graham, Deborah S.Kings Coll London, England
(författare)
-
Huang, Andrew J. W.University of Minnesota, MN USA
(författare)
-
Brennan, Michael T.Carolinas Medical Centre, NC 28203 USA
(författare)
-
Hughes, PamelaUniversity of Minnesota, MN USA
(författare)
-
Mei, Gabor G.MedImmune, MD USA; National Institute Dent and Craniofacial Research, MD USA
(författare)
-
Miceli-Richard, CorinneUniversity of Paris 11, France; INSERM, France
(författare)
-
Keystone, Edward C.Mt Sinai Hospital, Canada; University of Toronto, Canada
(författare)
-
Bykerk, Vivian P.Mt Sinai Hospital, Canada; University of Toronto, Canada; Hospital Special Surg, NY 10021 USA; Weill Cornell Med, NY USA
(författare)
-
Hirschfield, GideonUniversity of Birmingham, England
(författare)
-
Xie, GangMt Sinai Hospital, Canada; University of Toronto, Canada; Toronto Gen Hospital, Canada
(författare)
-
Ng, Wan-FaiNIHR Newcastle Biomed Research Centre, England
(författare)
-
Nordmark, GunnelUppsala University, Sweden
(författare)
-
Eriksson, Per,1958-Linköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Avdelningen för inflammation och infektion,Region Östergötland, Reumatologiska kliniken i Östergötland,Region Östergötland, Reumatologiska kliniken i Östergötland,Newcastle University, England(Swepub:liu)perer22
(författare)
-
Omda, RoaldStavanger University Hospital, Norway
(författare)
-
Rhodus, Nelson L.University of Minnesota, MN 55455 USA
(författare)
-
Rischmueller, MaureenQueen Elizabeth Hospital, Australia; University of Adelaide, Australia
(författare)
-
Rohrer, MichaelUniversity of Minnesota, MN USA
(författare)
-
Sega, Barbara M.University of Minnesota, MN 55455 USA; Hennepin County Medical Centre, MN 55415 USA
(författare)
-
Vvse, Timothy J.Kings Coll London, England
(författare)
-
Wahren-Herlenius, MarieKarolinska Institute, Sweden
(författare)
-
Witte, TorstenHannover Medical Sch, Germany
(författare)
-
Pons-Este, BernardoSanatorio Parque, Argentina
(författare)
-
Alarcon-Riquelme, Marta E.Oklahoma Medical Research Fdn, OK 73104 USA; Centre Pfizer University of Granada Junta de Andalucia Genom, Spain
(författare)
-
Guthridge, Joel M.Oklahoma Medical Research Fdn, OK 73104 USA
(författare)
-
James, Judith A.Oklahoma Medical Research Fdn, OK 73104 USA
(författare)
-
Lessard, Christopher J.Oklahoma Medical Research Fdn, OK 73104 USA
(författare)
-
Kelly, Jennifer A.Oklahoma Medical Research Fdn, OK 73104 USA
(författare)
-
Thompson, Susan D.University of Cincinnati, OH USA; Cincinnati Childrens Hospital Medical Centre, OH 45229 USA
(författare)
-
Gaffney, Patrick M.Oklahoma Medical Research Fdn, OK 73104 USA
(författare)
-
Montgomery, Courtney G.Oklahoma Medical Research Fdn, OK 73104 USA
(författare)
-
Edberg, Jeffrey C.University of Alabama Birmingham, AL USA
(författare)
-
Kimberly, Robert P.University of Alabama Birmingham, AL USA
(författare)
-
Alarcon, Gracicla S.University of Alabama Birmingham, AL USA
(författare)
-
Langefeld, Carl L.Wake Forest University, NC 27109 USA
(författare)
-
Gilkeson, Gary S.Medical University of S Carolina, SC USA
(författare)
-
Kamen, Diane L.Medical University of S Carolina, SC USA
(författare)
-
Tsao, Betty P.University of Calif Los Angeles, CA 90095 USA
(författare)
-
Joseph McCune, W.University of Michigan, MI 48109 USA
(författare)
-
Salmon, Jane E.Hospital Special Surg, NY 10021 USA; Weill Cornell Med, NY USA
(författare)
-
Merrill, Joan T.University of Oklahoma, OK USA; University of Oklahoma, OK 73190 USA
(författare)
-
Weisman, Michael H.Cedars Sinai Medical Centre, CA 90048 USA
(författare)
-
Wallace, Daniel J.Cedars Sinai Medical Centre, CA 90048 USA; University of Calif Los Angeles, CA 90095 USA
(författare)
-
Utset, TammyUniversity of Chicago, IL 60637 USA
(författare)
-
Bottinger, Erwin P.Mt Sinai Hospital, NY 10029 USA
(författare)
-
Amos, Christopher I.Dartmouth Coll, NH 03755 USA
(författare)
-
Siminovitch, Katherine A.Mt Sinai Hospital, Canada; University of Toronto, Canada; Toronto Gen Hospital, Canada
(författare)
-
Mariette, XavierUniversity of Paris 11, France; INSERM, France
(författare)
-
Sivils, Kathy L.Oklahoma Medical Research Fdn, OK 73104 USA
(författare)
-
Harley, John B.University of Cincinnati, OH USA; Cincinnati Childrens Hospital Medical Centre, OH 45229 USA; Cincinnati VA Medical Centre, OH USA
(författare)
-
Hal Scofield, R.University of Oklahoma, OK 73190 USA; Oklahoma City VA Medical Centre, OK USA
(författare)
-
University of Cincinnati, OH USA; Cincinnati Childrens Hospital Medical Centre, OH 45229 USAUniversity of Oklahoma, OK 73190 USA; Oklahoma City VA Medical Centre, OK USA
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:Arthritis & Rheumatology: WILEY-BLACKWELL68:5, s. 1290-13002326-51912326-5205
Internetlänk
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Liu, Ke
-
Kurien, Biji T.
-
Zimmerman, Sarah ...
-
Kaufman, Kenneth ...
-
Taft, Diana H.
-
Kottyan, Leah C.
-
visa fler...
-
Lazaro, Sara
-
Weaver, Carrie A ...
-
Ice, John A.
-
Adler, Adam J.
-
Chodosh, James
-
Radfar, Lida
-
Rasmussen, Astri ...
-
Stone, Donald U.
-
Lewis, David M.
-
Li, Shibo
-
Koelsch, Kristi ...
-
Igoe, Ann
-
Talsania, Mitali
-
Kumar, Jay
-
Maier-Moore, Jac ...
-
Harris, Valerie ...
-
Gopalakrishnan, ...
-
Jonsson, Roland
-
Lessard, James A ...
-
Lu, Xianglan
-
-Eric Gottenberg ...
-
-Manuel Anaya, J ...
-
Cunninghame-Grah ...
-
Huang, Andrew J. ...
-
Brennan, Michael ...
-
Hughes, Pamela
-
Mei, Gabor G.
-
Miceli-Richard, ...
-
Keystone, Edward ...
-
Bykerk, Vivian P ...
-
Hirschfield, Gid ...
-
Xie, Gang
-
Ng, Wan-Fai
-
Nordmark, Gunnel
-
Eriksson, Per, 1 ...
-
Omda, Roald
-
Rhodus, Nelson L ...
-
Rischmueller, Ma ...
-
Rohrer, Michael
-
Sega, Barbara M.
-
Vvse, Timothy J.
-
Wahren-Herlenius ...
-
Witte, Torsten
-
Pons-Este, Berna ...
-
Alarcon-Riquelme ...
-
Guthridge, Joel ...
-
James, Judith A.
-
Lessard, Christo ...
-
Kelly, Jennifer ...
-
Thompson, Susan ...
-
Gaffney, Patrick ...
-
Montgomery, Cour ...
-
Edberg, Jeffrey ...
-
Kimberly, Robert ...
-
Alarcon, Gracicl ...
-
Langefeld, Carl ...
-
Gilkeson, Gary S ...
-
Kamen, Diane L.
-
Tsao, Betty P.
-
Joseph McCune, W ...
-
Salmon, Jane E.
-
Merrill, Joan T.
-
Weisman, Michael ...
-
Wallace, Daniel ...
-
Utset, Tammy
-
Bottinger, Erwin ...
-
Amos, Christophe ...
-
Siminovitch, Kat ...
-
Mariette, Xavier
-
Sivils, Kathy L.
-
Harley, John B.
-
Hal Scofield, R.
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
- Artiklar i publikationen
-
Arthritis & Rheu ...
- Av lärosätet
-
Linköpings universitet