High Proton Relaxivity for Gadolinium Oxide Nanoparticles

Engström, MariaLinköpings universitet,Medicinsk radiologi,Hälsouniversitetet,Centrum för medicinsk bildvetenskap och visualisering, CMIV (författare)

Objective: Nanosized materials of gadolinium oxide can provide high-contrast enhancement in magnetic resonance imaging (MRI). The objective of the present study was to investigate proton relaxation enhancement by ultrasmall (5 to 10 nm) Gd2O3 nanocrystals.Materials and methods: Gd2O3 nanocrystals were synthesized by a colloidal method and capped with diethylene glycol (DEG). The oxidation state of Gd2O3 was confirmed by X-ray photoelectron spectroscopy. Proton relaxation times were measured with a 1.5-T MRI scanner. The measurements were performed in aqueous solutions and cell culture medium (RPMI).Results: Results showed a considerable relaxivity increase for the Gd2O3–DEG particles compared to Gd-DTPA. Both T 1 and T 2 relaxivities in the presence of Gd2O3–DEG particles were approximately twice the corresponding values for Gd–DTPA in aqueous solution and even larger in RPMI. Higher signal intensity at low concentrations was predicted for the nanoparticle solutions, using experimental data to simulate a T1-weighted spin echo sequence.Conclusion: The study indicates the possibility of obtaining at least doubled relaxivity compared to Gd–DTPA using Gd2O3–DEG nanocrystals as contrast agent. The high T 1 relaxation rate at low concentrations of Gd2O3 nanoparticles is very promising for future studies of contrast agents based on gadolinium-containing nanocrystals.

Klasson, AnnaLinköpings universitet,Medicinsk radiologi,Hälsouniversitetet,Centrum för medicinsk bildvetenskap och visualisering, CMIV(Swepub:liu)annkl89 (författare)
Pedersen, HenrikLinköpings universitet,Halvledarmaterial,Tekniska högskolan(Swepub:liu)henpe50 (författare)
Vahlberg, CecilliaLinköpings universitet,Sensorvetenskap och Molekylfysik,Tekniska högskolan(Swepub:liu)cecva95 (författare)
Käll, Per-OlovLinköpings universitet,Fysikalisk Kemi,Tekniska högskolan(Swepub:liu)perka28 (författare)
Uvdal, KajsaLinköpings universitet,Sensorvetenskap och Molekylfysik,Tekniska högskolan(Swepub:liu)kajuv09 (författare)
Linköpings universitetMedicinsk radiologi (creator_code:org_t)

Ingår i:Magnetic Resonance Materials in Physics, Biology and Medicine: Springer Science and Business Media LLC19:4, s. 180-1860968-52431352-8661

Av författaren/redakt...: Engström, Maria; Klasson, Anna; Pedersen, Henrik; Vahlberg, Cecill ...; Käll, Per-Olov; Uvdal, Kajsa

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