Synthesis and Characterization of Tb3+-Doped Gd2O3 Nanocrystals: A Bifunctional Material with Combined Fluorescent Labeling and MRI Contrast Agent Properties

Petoral, Rodrigo MLinköpings universitet,Molekylär ytfysik och nanovetenskap,Tekniska fakulteten (author)

Synthesis and Characterization of Tb3+-Doped Gd2O3 Nanocrystals : A Bifunctional Material with Combined Fluorescent Labeling and MRI Contrast Agent Properties

On the day of the defence date the status of this article was Submitted
Ultrasmall gadolinium oxide nanoparticles doped with terbium ions were synthesized by the polyol route and characterized as a potentially bifunctional material with both fluorescent and magnetic contrast agent properties. The structural, optical, and magnetic properties of the organic-acid-capped and PEGylated Gd2O3:Tb3+ nanocrystals were studied by HR-TEM, XPS, EDX, IR, PL, and SQUID. The luminescent/fluorescent property of the particles is attributable to the Tb3+ ion located on the crystal lattice of the Gd2O3 host. The paramagnetic behavior of the particles is discussed. Pilot studies investigating the capability of the nanoparticles for fluorescent labeling of living cells and as a MRI contrast agent were also performed. Cells of two cell lines (THP-1 cells and fibroblasts) were incubated with the particles, and intracellular particle distribution was visualized by confocal microscopy. The MRI relaxivity of the PEGylated nanoparticles in water at low Gd concentration was assessed showing a higher T-1 relaxation rate compared to conventional Gd-DTPA chelates and comparable to that of undoped Gd2O3 nanoparticles.

Söderlind, FredrikLinköpings universitet,Institutionen för fysik, kemi och biologi,Tekniska högskolan (author)
Klasson, AnnaÖstergötlands Läns Landsting,Linköpings universitet,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Medicinsk radiologi,Hälsouniversitetet,Röntgenkliniken i Linköping(Swepub:liu)annkl89 (author)
Suska, AnkeLinköpings universitet,Tillämpad Fysik,Tekniska fakulteten(Swepub:liu)anksu71 (author)
Fortin, Marc-AndréLinköpings universitet,Molekylär ytfysik och nanovetenskap,Tekniska fakulteten(Swepub:liu)marfo54 (author)
Abrikossova, NataliaLinköpings universitet,Molekylär ytfysik och nanovetenskap,Tekniska fakulteten(Swepub:liu)natab59 (author)
Selegard, LinneaLinköpings universitet,Sensorvetenskap och Molekylfysik,Tekniska högskolan (author)
Käll, Per-OlovLinköpings universitet,Fysikalisk Kemi,Tekniska högskolan(Swepub:liu)perka28 (author)
Engström, MariaÖstergötlands Läns Landsting,Linköpings universitet,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Medicinsk radiologi,Hälsouniversitetet,Röntgenkliniken i Linköping(Swepub:liu)maren21 (author)
Uvdal, KajsaLinköpings universitet,Molekylär ytfysik och nanovetenskap,Tekniska fakulteten(Swepub:liu)kajuv09 (author)
Linköpings universitetMolekylär ytfysik och nanovetenskap (creator_code:org_t)

In:The Journal of Physical Chemistry C: American Chemical Society (ACS)113:17, s. 6913-69201932-74471932-7455

By the author/editor: Petoral, Rodrigo ...; Söderlind, Fredr ...; Klasson, Anna; Suska, Anke; Fortin, Marc-And ...; Abrikossova, Nat ...; show more...; Selegard, Linnea; Käll, Per-Olov; Engström, Maria; Uvdal, Kajsa; show less...

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