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Review of SNP assay...
Review of SNP assays for disaster victim identification: Cost, time, and performance information for decision-makers
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- Gettings, Katherine Butler (author)
- Natl Inst Stand & Technol, MD USA
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- Tillmar, Andreas (author)
- Linköpings universitet,Avdelningen för molekylär medicin och virologi,Medicinska fakulteten,Natl Board Forens Med, Dept Forens Genet & Forens Toxicol, Linkoping, Sweden
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- Sturk-Andreaggi, Kimberly (author)
- 10 Def Hlth Agcy, DE USA; LLC Contractor Supporting AFMES AFDIL, VA USA
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- Marshall, Charla (author)
- 10 Def Hlth Agcy, DE USA; Penn State Univ, PA USA
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(creator_code:org_t)
- 2024
- 2024
- English.
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In: Journal of Forensic Sciences. - : WILEY. - 0022-1198 .- 1556-4029.
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- In mass disaster events, forensic DNA laboratories may be called upon to quickly pivot their operations toward identifying bodies and reuniting remains with family members. Ideally, laboratories have considered this possibility in advance and have a plan in place. Compared with traditional short tandem repeat (STR) typing, single nucleotide polymorphisms (SNPs) may be better suited to these disaster victim identification (DVI) scenarios due to their small genomic target size, resulting in an improved success rate in degraded DNA samples. As the landscape of technology has shifted toward DNA sequencing, many forensic laboratories now have benchtop instruments available for massively parallel sequencing (MPS), facilitating this operational pivot from routine forensic STR casework to DVI SNP typing. Herein, we present the commercially available SNP sequencing assays amenable to DVI, we use data simulations to explore the potential for kinship prediction from SNP panels of varying sizes, and we give an example DVI scenario as context for presenting the matrix of considerations: kinship predictive potential, cost, and throughput of current SNP assay options. This information is intended to assist laboratories in choosing a SNP system for disaster preparedness.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Annan medicin och hälsovetenskap -- Rättsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Other Medical and Health Sciences -- Forensic Science (hsv//eng)
Keyword
- disaster victim identification; DNA; DVI; extended kinship; human identification; massively parallel sequencing; SNP
Publication and Content Type
- ref (subject category)
- art (subject category)
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