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Treatment of platel...
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Sandgren, PerKarolinska Institutet,Karolinska University Hospital, Sweden; Karolinska Institute, Sweden
(författare)
Treatment of platelet concentrates with ultraviolet C light for pathogen reduction increases cytokine accumulation
- Artikel/kapitelEngelska2016
Förlag, utgivningsår, omfång ...
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2016-04-15
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WILEY-BLACKWELL,2016
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:liu-130296
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-130296URI
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https://doi.org/10.1111/trf.13601DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:133844139URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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Funding Agencies|Region Ostergotland; Linkoping Medical Society; MacoPharma
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BACKGROUNDPathogen reduction technologies use photoactive substances in combination with ultraviolet (UV) light to inactivate pathogens. A new method uses only UVC light for pathogen reduction. This study assesses the effects of UVC light treatment on cytokine release in platelet (PLT) concentrates (PCs). STUDY DESIGN AND METHODSA PC with 35% plasma and 65% PLT additive solution (SSP+) was prepared from five buffy coats. Three such PCs were pooled and divided into 3 units. One unit was used as a nonirradiated control, the second was a gamma-irradiated control, and the third unit was treated with UVC light technology. Ten units of each type were investigated. Cytokine release was analyzed on Days 1, 5, and 7 of storage. Correlation between cytokines, PLT surface markers, and hemostatic properties was investigated. RESULTSSwirling was well preserved and pH was above the reference limit of 6.4 during storage of PLTs in all groups. Cytokine levels increased during storage in all groups but to a larger degree in PCs treated with UVC light. Only weak correlation was found between cytokines and PLT surface markers (ramp;lt;0.5). However, several cytokines showed strong correlation (ramp;gt;0.6) with the PLTs ability to promote clot retraction. CONCLUSIONUVC treatment resulted in increased release from PLT alpha granules as evident by a higher cytokine release compared to nonirradiated and gamma-irradiated PCs. The clinical relevance of these findings needs to be further evaluated.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Berlin, GöstaLinköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Region Östergötland, Klinisk immunologi och transfusionsmedicin(Swepub:liu)gosbe95
(författare)
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Tynngård, NahreenLinköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Medicinska fakulteten,Region Östergötland, Klinisk kemi,Region Östergötland, Klinisk immunologi och transfusionsmedicin(Swepub:liu)nahty05
(författare)
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Karolinska InstitutetKarolinska University Hospital, Sweden; Karolinska Institute, Sweden
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Transfusion: WILEY-BLACKWELL56:6, s. 1377-13830041-11321537-2995
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