Optimization in biology parameter estimation and the associated optimization problem

• Parameter estimation – the assignment of values to the parameters in a model – is an important and time-consuming task in computational biology. Recent computational and algorithmic developments have provided novel tools to improve this estimation step. One of these improvements concerns the optimization step, where the parameter space is explored to find interesting regions. In this chapter we review the parameter estimation problem, with a special emphasis on the associated optimization methods. In relation to this, we also provide concepts and tools to help you select the appropriate methodology for a specific scenario.

Subject headings

TEKNIK OCH TEKNOLOGIER  -- Elektroteknik och elektronik -- Reglerteknik (hsv//swe)

ENGINEERING AND TECHNOLOGY  -- Electrical Engineering, Electronic Engineering, Information Engineering -- Control Engineering (hsv//eng)

Keyword

Parameter estimation

Optimization

Heuristic

Fitness function

Publication and Content Type

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