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High prevalence of ...
High prevalence of hospital-acquired infections caused by gram-negative carbapenem resistant strains in Vietnamese pediatric ICUs A multi-centre point prevalence survey
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- Le, Ngai Kien (author)
- Natl Hosp Pediat, Hanoi, Vietnam
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- Hanberger, Håkan (author)
- Linköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Medicinska fakulteten,Region Östergötland, Infektionskliniken i Östergötland
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- Vu, Phu Dinh (author)
- Natl Hosp Trop Dis, Hanoi, Vietnam
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- Khu, Dung Thi Khanh (author)
- Natl Hosp Pediat, Hanoi, Vietnam
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- Le, Hai Tanh (author)
- Natl Hosp Pediat, Hanoi, Vietnam
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- Hoang, Bich Thi Ngoc (author)
- Natl Hosp Pediat, Hanoi, Vietnam
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- Vo, Vu Thanh (author)
- HCMC, Childrens Hosp 1, Hanoi, Vietnam,Univ Oxford, Clin Res Unit, Hanoi, Vietnam; Univ Oxford, Ctr Trop Med, Nuffield Dept Med, Oxford OX1 2JD, England
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- Lam, YM (author)
- HCMC, Hosp Trop Dis, Hanoi, Vietnam
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- Vu, DTV (author)
- Univ Oxford, Clin Res Unit, Hanoi, Vietnam; Univ Oxford, Ctr Trop Med, Nuffield Dept Med, Oxford OX1 2JD, England
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- Nguyen, TH (author)
- Natl Hosp Pediat, Hanoi, Vietnam
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- Thai, TQ (author)
- HCMC, Childrens Hosp 1, Hanoi, Vietnam
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- Nilsson, Lennart E (author)
- Linköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Medicinska fakulteten
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- Rydell, Ulf (author)
- Linköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Medicinska fakulteten
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- Van Nguyen, K (author)
- HCMC, Hosp Trop Dis, Hanoi, Vietnam
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- Nadjm, Behzad (author)
- Univ Oxford, Clin Res Unit, Hanoi, Vietnam; Univ Oxford, Ctr Trop Med, Nuffield Dept Med, Oxford OX1 2JD, England
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- Clarkson, Louise (author)
- Karolinska Inst, Stockholm, Sweden
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- Hanberger, Håkan (author)
- Linköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Medicinska fakulteten,Region Östergötland, Infektionskliniken i Östergötland
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- Larsson, Mattias (author)
- Karolinska Institutet,University of Oxford, Vietnam; University of Oxford, England; Karolinska Institute, Sweden
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(creator_code:org_t)
- LIPPINCOTT WILLIAMS & WILKINS, 2016
- 2016
- English.
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In: Medicine. - : LIPPINCOTT WILLIAMS & WILKINS. - 0025-7974 .- 1536-5964. ; 95:27
- Related links:
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https://liu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- There is scarce information regarding hospital-acquired infections (HAIs) among children in resource-constrained settings. This study aims to measure prevalence of HAIs in Vietnamese pediatric hospitals. Monthly point prevalence surveys (PPSs) in 6 pediatric intensive care units (ICUs) in 3 referral hospitals during 1 year. A total of 1363 cases (1143 children) were surveyed, 59.9% male, average age 11 months. Admission sources were: other hospital 49.3%, current hospital 36.5%, and community 15.3%. Reasons for admission were: infectious disease (66%), noninfectious (20.8%), and surgery/trauma (11.3%). Intubation rate was 47.8%, central venous catheter 29.4%, peripheral venous catheter 86.2%, urinary catheter 14.6%, and hemodialysis/filtration 1.7%. HAI was diagnosed in 33.1% of the cases: pneumonia (52.2%), septicemia (26.4%), surgical site infection (2%), and necrotizing enterocolitis (2%). Significant risk factors for HAI included age under 7 months, intubation and infection at admission. Microbiological findings were reported in 212 cases (43%) with 276 isolates: 50 Klebsiella pneumoniae, 46 Pseudomonas aeruginosa, and 39 Acinetobacter baumannii, with carbapenem resistance detected in 55%, 71%, and 65%, respectively. Staphylococcus aureus was cultured in 18 cases, with 81% methicillin-resistant Staphylococcus aureus. Most children (87.6%) received antibiotics, with an average of 1.6 antibiotics per case. Colistin was administered to 96 patients, 93% with HAI and 49% with culture confirmed carbapenem resistance. The high prevalence of HAI with carbapenem resistant gram-negative strains and common treatment with broad-spectrum antibiotics and colistin suggests that interventions are needed to prevent HAI and to optimize antibiotic use.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Allmänmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- General Practice (hsv//eng)
Keyword
- hospital-acquired infections; ICU; pediatric; Vietnam
Publication and Content Type
- ref (subject category)
- art (subject category)
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Medicine
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To the university's database
- By the author/editor
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Le, Ngai Kien
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Hanberger, Håkan
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Vu, Phu Dinh
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Khu, Dung Thi Kh ...
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Le, Hai Tanh
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Hoang, Bich Thi ...
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Vo, Vu Thanh
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Lam, YM
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Vu, DTV
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Nguyen, TH
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Thai, TQ
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Nilsson, Lennart ...
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Rydell, Ulf
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Van Nguyen, K
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Nadjm, Behzad
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Clarkson, Louise
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Larsson, Mattias
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and General Practice
- Articles in the publication
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Medicine
- By the university
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Linköping University
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Karolinska Institutet