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Immunolocalization ...
Immunolocalization of E-cadherin and beta-catenin in the cyclic and early pregnant canine endometrium
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- Payan-Carreira, R. (författare)
- University of Tras Os Montes and Alto Douro, Portugal
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- Pires, M. A. (författare)
- University of Tras Os Montes and Alto Douro, Portugal
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- Santos, C. (författare)
- University of Tras Os Montes and Alto Douro, Portugal
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- Ström Holst, Bodil (författare)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för kliniska vetenskaper (KV),Department of Clinical Sciences,Swedish University of Agriculture Science SLU, Sweden
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- Colaco, J. (författare)
- University of Tras Os Montes and Alto Douro, Portugal
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- Rodriguez-Martinez, Heriberto (författare)
- Linköpings universitet,Avdelningen för kliniska vetenskaper,Medicinska fakulteten
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(creator_code:org_t)
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- ELSEVIER SCIENCE INC, 2016
- 2016
- Engelska.
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Ingår i: Theriogenology. - : ELSEVIER SCIENCE INC. - 0093-691X .- 1879-3231. ; 86:4, s. 1092-1101
- Relaterad länk:
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https://liu.diva-por... (primary) (Raw object)
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http://liu.diva-port...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://res.slu.se/i...
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Abstract
Ämnesord
Stäng
- Putative changes in E-cadherin and beta-catenin during implantation in dogs are of interest to study, as they are relevant proteins for epithelial integrity. E-cadherin and beta-catenin were immunolocalized in the canine endometrium during the estrous cycle and early pregnancy, using monoclonal antibodies. Both proteins were detected in all types of endometrial epithelia (surface epithelium [SE], superficial glandular, and deep glandular epithelia) at all stages of the estrous cycle and in early placental structures. E-cadherin depicted a gradient of intensity apparently being lowest in the SE to progressively increase toward the deepness of the endometrial glands, regardless of the stage of estrous cycle. The overall immunostaining was, however, weaker at diestrus. In pregnant samples, the trophoblast was conspicuously immunolabeled compared with the endometrial surface lining epithelium. In the latter, the cytoplasmic pattern predominated over the membrane bound, as was also seen in the decidual cells of the placental labyrinth. In the early placenta, only trophoblast cells and lacunae retained membrane signals. beta-Catenin membrane labeling appeared relatively constant throughout the cycle, although a tendency toward a decrease in intensity was detected at the secretory stages. In addition, a dislocation of the immunoreaction from membrane to the cytoplasm was observed in both the SE and the glandular epithelia at particular stages of the cycle. In early pregnancy, a loss of the membranous pattern was observed in the SE and labyrinth, but neither on trophoblast nor in lacunae. The results show the existence of a softening of the adherens junctional complex in progestagen-dominated stages favoring embryo-maternal interactions and endometrial invasion during canine implantation. (C) 2016 Elsevier Inc. All rights reserved.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
- LANTBRUKSVETENSKAPER -- Veterinärmedicin -- Klinisk vetenskap (hsv//swe)
- AGRICULTURAL SCIENCES -- Veterinary Science -- Clinical Science (hsv//eng)
Nyckelord
- E-Cadherin; beta-Catenin; Canine endometrium; Estrous cycle; Early pregnancy; Dog
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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