High levels of IgG4 antibodies to foods during infancy are associated with tolerance to corresponding foods later in life

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Tomičić, SaraLinköpings universitet,Pediatrik,Hälsouniversitetet (author)

High levels of IgG4 antibodies to foods during infancy are associated with tolerance to corresponding foods later in life

Article/chapterEnglish2009

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Wiley,2009
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LIBRIS-ID:oai:DiVA.org:liu-13205
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-13205URI
https://doi.org/10.1111/j.1399-3038.2008.00738.xDOI

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Language:English
Summary in:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

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The fulltext of this work is available at Blackwell-Syergy: Sara Tomičić, Gunilla Norrman, Karin Fälth-Magnusson, Maria C. Jenmalm, Irene Devenney and Malin Fagerås Böttcher, High levels of IgG4 antibodies to foods during infancy are associated with tolerance to corresponding foods later in life, 2008, Pediatric Allergy and Immunology, (5), 1, 35-41. http://dx.doi.org/10.1111/j.1399-3038.2008.00738.x Copyright: Blackwell-Synergy http://www.blackwellpublishing.com/
Children with eczema and sensitization to foods are recommended skin care and, if food allergy is proven by challenge, an elimination diet. For most children the diet period is transient, but the process behind tolerance development and the influence of decreased allergen exposure is not fully known. The aim of the study was to investigate the effect of elimination diet on serum and salivary antibodies and to identify immunological parameters related to the ability to tolerate foods. Eighty-nine children, below 2 yr of age, with eczema and suspected food allergy were included. Recommended treatment was skin care to all children, and 60 children had a period of elimination diet. At 4½ yr of age, the children were divided into two groups, based on if they had been able to introduce the eliminated foods, or not. Serum and salivary antibodies were analyzed with enzyme-linked immunosorbent assay and UniCAP® before and after a 6-wk treatment period and at 4½ yr of age. Children sensitized to egg and/or milk that could eat and drink the offending foods at 4½ yr of age, had higher levels of Immunoglobulin G4 antibodies to ovalbumin and β-lactoglobulin and also higher IgG4/Immunoglobulin E ratios on inclusion in the study, than those who had to eliminate egg and/or milk from their diet, beyond 4½ yr of age. The highest IgG4/IgE ratios were found in children with circulating IgE antibodies to egg and/or milk but negative skin prick test on inclusion. The 6-wk treatment period did not significantly affect the levels of serum and salivary antibodies. In conclusion, eczematous, food sensitized infants with high levels of IgG4 and high ratios of IgG4/IgE antibodies to food allergens are more likely to consume these foods at 4½ yr than infants with low levels and ratios.

Subject headings and genre

food allergy
elimination diet
tolerance
immunoglobulin G4
eczema
children
immunoglobulin E
MEDICINE
MEDICIN

Added entries (persons, corporate bodies, meetings, titles ...)

Norrman, GunillaLinköpings universitet,Pediatrik,Hälsouniversitetet(Swepub:liu)gunjo87 (author)
Fälth-Magnusson, KarinÖstergötlands Läns Landsting,Linköpings universitet,Pediatrik,Hälsouniversitetet,Barn- och ungdomskliniken i Linköping(Swepub:liu)karfa12 (author)
Jenmalm, Maria C.Linköpings universitet,Pediatrik,Hälsouniversitetet(Swepub:liu)marje18 (author)
Devenney, IreneÖstergötlands Läns Landsting,Linköpings universitet,Pediatrik,Hälsouniversitetet,Barn- och ungdomskliniken i Linköping(Swepub:liu)irede24 (author)
Fagerås Böttcher, MalinLinköpings universitet,Pediatrik,Hälsouniversitetet(Swepub:liu)malfa24 (author)
Linköpings universitetPediatrik (creator_code:org_t)

Related titles

In:Pediatric Allergy and Immunology: Wiley5:1, s. 35-410905-61571399-3038

Internet link

http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-11615Link to Tomicic Ph.D.Thesis
http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-9048Link to Norrman Ph.D. Thesis
https://liu.diva-portal.org/smash/get/diva2:18031/FULLTEXT01.pdffulltext:postprint
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1399-3038.2008.00738.x
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-13205
https://doi.org/10.1111/j.1399-3038.2008.00738.x

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