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Long-term Kidney Tr...
Long-term Kidney Transplant Outcomes in Primary Glomerulonephritis: Analysis From the ERA-EDTA Registry
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- Pippias, Maria (author)
- University of Amsterdam, Netherlands
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- Stel, Vianda S. (author)
- University of Amsterdam, Netherlands
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- Areste-Fosalba, Nuria (author)
- University Hospital Virgen Macarena, Spain
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- Couchoud, Cecile (author)
- Agence Biomed, France
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- Fernandez-Fresnedo, Gema (author)
- University Hospital Marques de Valdecilla, Spain
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- Finne, Patrik (author)
- University of Helsinki, Finland; Finnish Registry Kidney Disease, Finland
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- Heaf, James G. (author)
- University of Copenhagen, Denmark
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- Hoitsma, Andries (author)
- Radboud University of Nijmegen, Netherlands
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- De Meester, Johan (author)
- Dutch Speaking Belgian Renal Registry NBVN, Belgium
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- Palsson, Runolfur (author)
- Landspitali, Iceland; Fac Med, Iceland; University of Iceland, Iceland
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- Ravani, Pietro (author)
- University of Calgary, Canada; University of Calgary, Canada
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- Segelmark, Mårten (author)
- Linköpings universitet,Avdelningen för läkemedelsforskning,Medicinska fakulteten,Region Östergötland, Njurmedicinska kliniken US
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- Traynor, Jamie P. (author)
- Meridian Court, Scotland
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- Reisaeter, Anna V. (author)
- National Hospital Norway, Norway
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- Caskey, Fergus J. (author)
- Southmead Hospital, England; University of Bristol, England
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- Jager, Kitty J. (author)
- University of Amsterdam, Netherlands
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(creator_code:org_t)
- LIPPINCOTT WILLIAMS & WILKINS, 2016
- 2016
- English.
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In: Transplantation. - : LIPPINCOTT WILLIAMS & WILKINS. - 0041-1337 .- 1534-6080. ; 100:9, s. 1955-1962
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Background We evaluated the 15-year kidney allograft survival in patients with primary glomerulonephritis and determined if the risk of graft loss varied with donor source within each glomerulonephritis group. Methods Using data from the European Renal Association-European Dialysis and Transplant Association Registry, Kaplan-Meier, competing risk, and Cox regression analyses were performed on adult, first kidney transplant recipients during 1991 to 2010 (n = 14 383). Follow-up was set to December 31, 2011. Adjustments for pretransplant dialysis duration, sex, country, and transplant era were made. Death-adjusted graft survival was assessed in patients with glomerulonephritis and compared with those with autosomal dominant polycystic kidney disease (ADPKD), in which the native kidney disease cannot recur. Additionally, death-adjusted graft survival was compared between living and deceased donor transplants within each glomerulonephritis group. Results All glomerulonephritides had a 15-year death-adjusted graft survival probability above 55%. The 15-year risk of death-adjusted graft failure compared to ADPKD ranged from 1.17 (95% confidence interval [95% CI], 1.05-1.31) for immunoglobulin A nephropathy to 2.09 (95% CI, 1.56-2.78) for membranoproliferative glomerulonephritis type II. The expected survival benefits of living over deceased donor transplants were not present in membranoproliferative glomerulonephritis type I (adjusted hazard ratios [HRa], 1.08; 95% CI, 0.73-1.60) or type II (HRa, 0.90; 95% CI, 0.32-2.52) but present in immunoglobulin A nephropathy (HRa, 0.74; 95% CI, 0.59-0.92), membranous nephropathy (HRa, 0.47; 95% CI, 0.29-0.75), and focal segmental glomerulosclerosis (HRa, 0.69; 95% CI, 0.45-1.06). Conclusions This large European study shows favorable long-term kidney graft survival in all primary glomerulonephritides, although this remains lower than graft survival in ADPKD, and confirms that the reluctance to use living donors in some primary glomerulonephritides remains unfounded. These data will further inform prospective renal transplant recipients and donors during pretransplant counselling.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
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- art (subject category)
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- By the author/editor
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Pippias, Maria
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Stel, Vianda S.
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Areste-Fosalba, ...
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Couchoud, Cecile
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Fernandez-Fresne ...
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Finne, Patrik
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Heaf, James G.
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Hoitsma, Andries
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De Meester, Joha ...
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Palsson, Runolfu ...
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Ravani, Pietro
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Segelmark, Mårte ...
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Traynor, Jamie P ...
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Reisaeter, Anna ...
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Caskey, Fergus J ...
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Jager, Kitty J.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Urology and Neph ...
- Articles in the publication
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Transplantation
- By the university
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Linköping University