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Depression-like beh...
Depression-like behavior in rat: Involvement of galanin receptor subtype 1 in the ventral periaqueductal gray
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- Wang, Peng (author)
- Capital Medical University, Peoples R China; Logist University of Peoples Armed Police Force, Peoples R China
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- Li, Hui (author)
- Capital Medical University, Peoples R China
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- Barde, Swapnali (author)
- Karolinska Institutet,Karolinska Institute, Sweden
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- Zhang, Ming-Dong (author)
- Karolinska Institutet,Karolinska Institute, Sweden; Karolinska Institute, Sweden
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- Sun, Jing (author)
- Capital Medical University, Peoples R China
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- Wang, Tong (author)
- Capital Medical University, Peoples R China
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- Zhang, Pan (author)
- Capital Medical University, Peoples R China
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- Luo, Hanjiang (author)
- Capital Medical University, Peoples R China
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- Wang, Yongjun (author)
- Capital Medical University, Peoples R China
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- Yang, Yutao (author)
- Capital Medical University, Peoples R China
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- Wang, Chuanyue (author)
- Capital Medical University, Peoples R China
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- Svenningsson, Per (author)
- Karolinska Institutet,Karolinska Institute, Sweden; Karolinska University Hospital, Sweden
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- Theodorsson, Elvar (author)
- Linköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Medicinska fakulteten,Region Östergötland, Klinisk kemi
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- Hokfelt, Tomas G. M. (author)
- Karolinska Institute, Sweden
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- David Xu, Zhi-Qing (author)
- Karolinska Institutet,Capital Medical University, Peoples R China
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(creator_code:org_t)
- 2016-07-25
- 2016
- English.
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In: Proceedings of the National Academy of Sciences of the United States of America. - : NATL ACAD SCIENCES. - 0027-8424 .- 1091-6490. ; 113:32, s. E4726-E4735
- Related links:
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https://www.pnas.org...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
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- The neuropeptide galanin coexists in rat brain with serotonin in the dorsal raphe nucleus and with noradrenaline in the locus coeruleus (LC), and it has been suggested to be involved in depression. We studied rats exposed to chronic mild stress (CMS), a rodent model of depression. As expected, these rats showed several endophenotypes relevant to depression-like behavior compared with controls. All these endophenotypes were normalized after administration of a selective serotonin reuptake inhibitor. The transcripts for galanin and two of its receptors, galanin receptor 1 (GALR1) and GALR2, were analyzed with quantitative real-time PCR using laser capture microdissection in the following brain regions: the hippocampal formation, LC, and ventral periaqueductal gray (vPAG). Only Galr1 mRNA levels were significantly increased, and only in the latter region. After knocking down Galr1 in the vPAG with an siRNA technique, all parameters of the depressive behavioral phenotype were similar to controls. Thus, the depression-like behavior in rats exposed to CMS is likely related to an elevated expression of Galr1 in the vPAG, suggesting that a GALR1 antagonist could have antidepressant effects.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- dorsal raphe; neuropeptide; siRNA; stress; transmitter coexistence
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Wang, Peng
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Li, Hui
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Barde, Swapnali
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Zhang, Ming-Dong
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Sun, Jing
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Wang, Tong
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Zhang, Pan
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Luo, Hanjiang
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Wang, Yongjun
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Yang, Yutao
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Wang, Chuanyue
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Svenningsson, Pe ...
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Theodorsson, Elv ...
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Hokfelt, Tomas G ...
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David Xu, Zhi-Qi ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Proceedings of t ...
- By the university
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Linköping University
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Karolinska Institutet