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MicroRNA-20a-5p pro...
MicroRNA-20a-5p promotes colorectal cancer invasion and metastasis by downregulating Smad4
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- Cheng, Dantong (författare)
- Shanghai Jiao Tong University, Peoples R China
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- Zhao, Senlin (författare)
- Linköpings universitet,Avdelningen för kliniska vetenskaper,Medicinska fakulteten,Shanghai Jiao Tong University, Peoples R China
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- Tang, Huamei (författare)
- Shanghai Jiao Tong University, Peoples R China
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- Zhang, Dongyuan (författare)
- Shanghai Jiao Tong University, Peoples R China
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- Sun, Hongcheng (författare)
- Shanghai Jiao Tong University, Peoples R China
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- Yu, Fudong (författare)
- Shanghai Jiao Tong University, Peoples R China
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- Jiang, Weiliang (författare)
- Shanghai Jiao Tong University, Peoples R China
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- Yue, Ben (författare)
- Shanghai Jiao Tong University, Peoples R China
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- Wang, Jingtao (författare)
- Shanghai Jiao Tong University, Peoples R China
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- Zhang, Meng (författare)
- Fudan University, Peoples R China
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- Yu, Yang (författare)
- Shanghai Jiao Tong University, Peoples R China
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- Liu, Xisheng (författare)
- Shanghai Jiao Tong University, Peoples R China
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- Sun, Xiao-Feng (författare)
- Linköpings universitet,Avdelningen för kliniska vetenskaper,Medicinska fakulteten,Region Östergötland, Onkologiska kliniken US
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- Zhou, Zongguang (författare)
- Sichuan University, Peoples R China
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- Qin, Xuebin (författare)
- Temple University, PA 19122 USA
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- Zhang, Xin (författare)
- Zhejiang Prov Peoples Hospital, Peoples R China
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- Yan, Dongwang (författare)
- Shanghai Jiao Tong University, Peoples R China
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- Wen, Yugang (författare)
- Linköpings universitet,Avdelningen för Kirurgi, Ortopedi och Onkologi,Medicinska fakulteten,Region Östergötland, Onkologiska kliniken US,Shanghai Jiao Tong University, Peoples R China
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- Peng, Zhihai (författare)
- Shanghai Jiao Tong University, Peoples R China
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(creator_code:org_t)
- 2016-06-07
- 2016
- Engelska.
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Ingår i: Oncotarget. - : IMPACT JOURNALS LLC. - 1949-2553. ; 7:29, s. 45199-45213
- Relaterad länk:
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https://liu.diva-por... (primary) (Raw object)
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http://www.oncotarge...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: Tumor metastasis is one of the leading causes of poor prognosis for colorectal cancer (CRC) patients. Loss of Smad4 contributes to aggression process in many human cancers. However, the underlying precise mechanism of aberrant Smad4 expression in CRC development is still little known. Results: miR-20a-5p negatively regulated Smad4 by directly targeting its 3UTR in human colorectal cancer cells. miR-20a-5p not only promoted CRC cells aggression capacity in vitro and liver metastasis in vivo, but also promoted the epithelial-to-mesenchymal transition process by downregulating Smad4 expression. In addition, tissue microarray analysis obtained from 544 CRC patients clinical characters showed that miR-20a-5p was upregulated in human CRC tissues, especially in the tissues with metastasis. High level of miR-20a-5p predicted poor prognosis in CRC patients. Methods: Five miRNA target prediction programs were applied to identify potential miRNA(s) that target(s) Smad4 in CRC. Luciferase reporter assay and transfection technique were used to validate the correlation between miR-20a-5p and Smad4 in CRC. Wound healing, transwell and tumorigenesis assays were used to explore the function of miR-20a-5p and Smad4 in CRC progression in vitro and in vivo. The association between miR-20a-5p expression and the prognosis of CRC patients was evaluated by Kaplan-Meier analysis and multivariate cox proportional hazard analyses based on tissue microarray data. Conclusions: miR-20a-5p, as an onco-miRNA, promoted the invasion and metastasis ability by suppressing Smad4 expression in CRC cells, and high miR-20a-5p predicted poor prognosis for CRC patients, providing a novel and promising therapeutic target in human colorectal cancer.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- miR-20a-5p; colorectal cancer; metastasis; prognosis; Smad4
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Cheng, Dantong
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Zhao, Senlin
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Tang, Huamei
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Zhang, Dongyuan
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Sun, Hongcheng
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Yu, Fudong
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visa fler...
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Jiang, Weiliang
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Yue, Ben
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Wang, Jingtao
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Zhang, Meng
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Yu, Yang
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Liu, Xisheng
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Sun, Xiao-Feng
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Zhou, Zongguang
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Qin, Xuebin
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Zhang, Xin
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Yan, Dongwang
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Wen, Yugang
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Peng, Zhihai
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
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Oncotarget
- Av lärosätet
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Linköpings universitet