Metabolic Health in Childhood Cancer Survivors: A Longitudinal Study in a Long-Term Follow-Up Clinic

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Gunn, Harriet M.Childrens Hospital Westmead, Australia; University of Sydney, Australia (författare)

Metabolic Health in Childhood Cancer Survivors: A Longitudinal Study in a Long-Term Follow-Up Clinic

Artikel/kapitelEngelska2016

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MARY ANN LIEBERT, INC,2016
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LIBRIS-ID:oai:DiVA.org:liu-132558
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-132558URI
https://doi.org/10.1089/jayao.2015.0036DOI

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Språk:engelska
Sammanfattning på:engelska

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Purpose: Childhood cancer survivors (CCS) are at increased risk of metabolic dysfunction as a late effect of cancer treatment. However, pediatric metabolic syndrome (MetS) lacks a unified definition, limiting the diagnosis of MetS in CCS. This study evaluated individual metabolic health risk factors and potential areas for intervention in this at-risk population. Methods: This single center, retrospective observational longitudinal study evaluated the metabolic health of all CCS attending an oncology long-term follow-up clinic at a university hospital in Sydney, Australia (January 2012-August 2014). Participants were 276 CCS (52.2% male; mean age 18.0 years; range 6.8-37.9 years), at least 5 years disease free with a broad spectrum of oncological diagnoses. Primary metabolic health risk factors included raised body mass index, hypertension, and hypertransaminasemia. Participants treated with cranial radiotherapy (n=47; 17.0% of cohort) had additional biochemical variables analyzed: fasting glucose/insulin, HDL/LDL cholesterol, and triglycerides. Results: Hypertension was common (19.0%), with male sex (pamp;lt;0.01) and being aged 18 years or above (pamp;lt;0.01) identified as risk factors. Cranial irradiation was a risk factor for overweight/obesity (47.8% in cranial radiotherapy-treated participants vs. 30.4%; p=0.02). Hypertransaminasemia was more prevalent among participants treated with radiotherapy (15.6% vs. 7.3%; p=0.03), and overweight/obese participants (17.6% vs. 8.2%; p=0.04). Conclusion: Metabolic health risk factors comprising MetS are common in CCS, placing this population at risk of premature adverse cardiovascular consequences. Proactive surveillance and targeted interventions are required to minimize these metabolic complications, and a unified definition for pediatric MetS would improve identification and monitoring.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Allmänmedicin hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine General Practice hsv//eng
metabolic; obesity; overweight; hypertension; non-alcoholic fatty liver disease

Biuppslag (personer, institutioner, konferenser, titlar ...)

Emilsson, HannaLinköpings universitet,Medicinska fakulteten (författare)
Gabriel, MelissaChildrens Hospital Westmead, Australia (författare)
Maguire, Ann M.Childrens Hospital Westmead, Australia; University of Sydney, Australia (författare)
Steinbeck, Katharine S.Childrens Hospital Westmead, Australia; University of Sydney, Australia (författare)
Childrens Hospital Westmead, Australia; University of Sydney, AustraliaMedicinska fakulteten (creator_code:org_t)

Sammanhörande titlar

Ingår i:Journal of Adolescent and Young Adult Oncology: MARY ANN LIEBERT, INC5:1, s. 24-302156-53332156-535X

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Journal of Adolescent and Young Adult Oncology (Sök värdpublikationen i LIBRIS)

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Av författaren/redakt...: Gunn, Harriet M.; Emilsson, Hanna; Gabriel, Melissa; Maguire, Ann M.; Steinbeck, Katha ...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Allmänmedicin

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Av lärosätet: Linköpings universitet

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