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De novo design of a...
De novo design of a biologically active amyloid
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- Gallardo, Rodrigo (author)
- VIB Switch Lab, Belgium; Katholieke University of Leuven, Belgium
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- Ramakers, Meine (author)
- VIB Switch Lab, Belgium; Katholieke University of Leuven, Belgium
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- De Smet, Frederik (author)
- VIB Switch Lab, Belgium; Katholieke University of Leuven, Belgium
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- Claes, Filip (author)
- VIB Switch Lab, Belgium; Katholieke University of Leuven, Belgium
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- Khodaparast, Ladan (author)
- VIB Switch Lab, Belgium; Katholieke University of Leuven, Belgium; Katholieke University of Leuven, Belgium
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- Khodaparast, Laleh (author)
- VIB Switch Lab, Belgium; Katholieke University of Leuven, Belgium; Katholieke University of Leuven, Belgium
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- Couceiro, Jose R. (author)
- VIB Switch Lab, Belgium; Katholieke University of Leuven, Belgium
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- Langenberg, Tobias (author)
- VIB Switch Lab, Belgium; Katholieke University of Leuven, Belgium
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- Siemons, Maxime (author)
- VIB Switch Lab, Belgium; Katholieke University of Leuven, Belgium; Katholieke University of Leuven, Belgium
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- Nyström, Sofie (author)
- Linköpings universitet,Kemi,Tekniska fakulteten
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- Young, Laurence J. (author)
- University of Cambridge, England; University of Leeds, England; University of Leeds, England
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- Laine, Romain F. (author)
- University of Cambridge, England
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- Young, Lydia (author)
- University of Cambridge, England; University of Leeds, England; University of Leeds, England
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- Radaelli, Enrico (author)
- VIB Centre Biol Disease, Belgium; Katholieke University of Leuven, Belgium; Katholieke University of Leuven, Belgium
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- Benilova, Iryna (author)
- VIB Centre Biol Disease, Belgium; Katholieke University of Leuven, Belgium; Katholieke University of Leuven, Belgium
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- Kumar, Manoj (author)
- Katholieke University of Leuven, Belgium
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- Staes, An (author)
- VIB, Belgium; University of Ghent, Belgium
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- Desager, Matyas (author)
- VIB Switch Lab, Belgium; Katholieke University of Leuven, Belgium; Katholieke University of Leuven, Belgium
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- Beerens, Manu (author)
- Katholieke University of Leuven, Belgium
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- Vandervoort, Petra (author)
- Katholieke University of Leuven, Belgium
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- Luttun, Aernout (author)
- Katholieke University of Leuven, Belgium
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- Gevaert, Kris (author)
- VIB, Belgium; University of Ghent, Belgium
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- Bormans, Guy (author)
- Katholieke University of Leuven, Belgium
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- Dewerchin, Mieke (author)
- Katholieke University of Leuven, Belgium; VIB, Belgium
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- Van Eldere, Johan (author)
- Katholieke University of Leuven, Belgium
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- Carmeliet, Peter (author)
- Katholieke University of Leuven, Belgium; VIB, Belgium
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- Vande Velde, Greetje (author)
- Katholieke University of Leuven, Belgium
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- Verfaillie, Catherine (author)
- Katholieke University of Leuven, Belgium
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- Kaminski, Clemens F. (author)
- University of Cambridge, England
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- De Strooper, Bart (author)
- VIB Centre Biol Disease, Belgium; Katholieke University of Leuven, Belgium; Katholieke University of Leuven, Belgium
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- Hammarström, Per (author)
- Linköpings universitet,Kemi,Tekniska fakulteten
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- Nilsson, Peter (author)
- Linköpings universitet,Kemi,Tekniska fakulteten
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- Serpell, Louise (author)
- University of Sussex, England
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- Schymkowitz, Joost (author)
- VIB Switch Lab, Belgium; Katholieke University of Leuven, Belgium
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- Rousseau, Frederic (author)
- VIB Switch Lab, Belgium; Katholieke University of Leuven, Belgium
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(creator_code:org_t)
- AMER ASSOC ADVANCEMENT SCIENCE, 2016
- 2016
- English.
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In: Science. - : AMER ASSOC ADVANCEMENT SCIENCE. - 0036-8075 .- 1095-9203. ; 354:6313, s. 720-
- Related links:
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http://eprints.white...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Most human proteins possess amyloidogenic segments, but only about 30 are associated with amyloid-associated pathologies, and it remains unclear what determines amyloid toxicity. We designed vascin, a synthetic amyloid peptide, based on an amyloidogenic fragment of vascular endothelial growth factor receptor 2 (VEGFR2), a protein that is not associated to amyloidosis. Vascin recapitulates key biophysical and biochemical characteristics of natural amyloids, penetrates cells, and seeds the aggregation of VEGFR2 through direct interaction. We found that amyloid toxicity is observed only in cells that both express VEGFR2 and are dependent on VEGFR2 activity for survival. Thus, amyloid toxicity here appears to be both protein-specific and conditional-determined by VEGFR2 loss of function in a biological context in which target protein function is essential.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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Gallardo, Rodrig ...
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Ramakers, Meine
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De Smet, Frederi ...
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Claes, Filip
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Khodaparast, Lad ...
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Khodaparast, Lal ...
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show more...
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Couceiro, Jose R ...
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Langenberg, Tobi ...
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Siemons, Maxime
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Nyström, Sofie
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Young, Laurence ...
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Laine, Romain F.
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Young, Lydia
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Radaelli, Enrico
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Benilova, Iryna
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Kumar, Manoj
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Staes, An
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Desager, Matyas
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Beerens, Manu
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Vandervoort, Pet ...
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Luttun, Aernout
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Gevaert, Kris
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Bormans, Guy
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Dewerchin, Mieke
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Van Eldere, Joha ...
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Carmeliet, Peter
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Vande Velde, Gre ...
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Verfaillie, Cath ...
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Kaminski, Clemen ...
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De Strooper, Bar ...
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Hammarström, Per
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Nilsson, Peter
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Serpell, Louise
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Schymkowitz, Joo ...
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Rousseau, Freder ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Medical Biotechn ...
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and Medical Biotechn ...
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Science
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Linköping University