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Immunogold detectio...
Immunogold detection of L-glutamate and D-serine in small synaptic-like microvesicles in adult hippocampal astrocytes.
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- Bergersen, L H (författare)
- Department of Anatomy, Centre for Molecular Biology and Neuroscience, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
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- Morland, C (författare)
- Department of Anatomy, Centre for Molecular Biology and Neuroscience, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
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- Ormel, L (författare)
- Department of Anatomy, Centre for Molecular Biology and Neuroscience, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
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- Rinholm, J E (författare)
- Department of Anatomy, Centre for Molecular Biology and Neuroscience, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
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- Larsson, Max (författare)
- Department of Anatomy, Centre for Molecular Biology and Neuroscience, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
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- Wold, J F H (författare)
- Department of Anatomy, Centre for Molecular Biology and Neuroscience, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
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- Røe, A T (författare)
- Department of Anatomy, Centre for Molecular Biology and Neuroscience, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
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- Stranna, A (författare)
- Department of Anatomy, Centre for Molecular Biology and Neuroscience, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
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- Santello, M (författare)
- Département de Biologie Cellulaire et de Morphologie, Université de Lausanne, Lausanne, Switzerland
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- Bouvier, D (författare)
- Département de Biologie Cellulaire et de Morphologie, Université de Lausanne, Lausanne, Switzerland
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- Ottersen, O P (författare)
- Department of Anatomy, Centre for Molecular Biology and Neuroscience, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
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- Volterra, A (författare)
- Département de Biologie Cellulaire et de Morphologie, Université de Lausanne, Lausanne, Switzerland
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- Gundersen, V (författare)
- Department of Anatomy, Centre for Molecular Biology and Neuroscience, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway; Department of Neurology, Oslo University Hospital, Rikshospitalet, Oslo, Norway
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(creator_code:org_t)
- 2011-09-12
- 2012
- Engelska.
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Ingår i: Cerebral Cortex. - : Oxford University Press. - 1047-3211 .- 1460-2199. ; 22:7, s. 1690-1697
- Relaterad länk:
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https://academic.oup...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Glutamate and the N-methyl-D-aspartate receptor ligand D-serine are putative gliotransmitters. Here, we show by immunogold cytochemistry of the adult hippocampus that glutamate and D-serine accumulate in synaptic-like microvesicles (SLMVs) in the perisynaptic processes of astrocytes. The estimated concentration of fixed glutamate in the astrocytic SLMVs is comparable to that in synaptic vesicles of excitatory nerve terminals (≈ 45 and ≈ 55 mM, respectively), whereas the D-serine level is about 6 mM. The vesicles are organized in small spaced clusters located near the astrocytic plasma membrane. Endoplasmic reticulum is regularly found in close vicinity to SLMVs, suggesting that astrocytes contain functional nanodomains, where a local Ca(2+) increase can trigger release of glutamate and/or D-serine.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- gliotransmitter
- gold particles
- rat
- ultrastructure
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Bergersen, L H
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Morland, C
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Ormel, L
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Rinholm, J E
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Larsson, Max
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Wold, J F H
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visa fler...
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Røe, A T
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Stranna, A
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Santello, M
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Bouvier, D
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Ottersen, O P
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Volterra, A
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Gundersen, V
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visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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Cerebral Cortex
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