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Sökning: id:"swepub:oai:DiVA.org:liu-133256" > Managing reversal o...

  • Ageno, WalterUniversity of Insubria, Italy (författare)

Managing reversal of direct oral anticoagulants in emergency situations Anticoagulation Education Task Force White Paper

  • Artikel/kapitelEngelska2016

Förlag, utgivningsår, omfång ...

  • SCHATTAUER GMBH-VERLAG MEDIZIN NATURWISSENSCHAFTEN,2016
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:liu-133256
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-133256URI
  • https://doi.org/10.1160/TH16-05-0363DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding Agencies|Boehringer Ingelheim
  • Anticoagulation is the cornerstone of prevention and treatment of venous thromboembolism (VTE) and stroke prevention in patients with atrial fibrillation (AF). However, the mechanisms by which anticoagulants confer therapeutic benefit also increase the risk of bleeding. As such, reversal strategies are critical. Until recently, the direct oral anticoagulants (DOACs) dabigatran, rivaroxaban, apixaban, and edoxaban lacked a specific reversal agent. This report is based on findings from the Anticoagulation Education Task Force, which brought together patient groups and professionals representing different medical specialties with an interest in patient safety and expertise in AF, VTE, stroke, anticoagulation, and reversal agents, to discuss the current status of anticoagulation reversal and fundamental changes in management of bleeding associated with DOACs occasioned by the approval of idarucizumab, a specific reversal agent for dabigatran, as well as recent clinical data on specific reversal agents for factor Xa inhibitors. Recommendations are given for when there is a definite need for a reversal agent (e.g. in cases of life-threatening bleeding, bleeding into a closed space or organ, persistent bleeding despite local haemostatic measures, and need for urgent interventions and/or interventions that carry a high risk for bleeding), when reversal agents may be helpful, and when a reversal agent is generally not needed. Key stakeholders who require 24-7/around-the-clock access to these agents vary among hospitals; however, from a practical perspective the emergency department is recommended as an appropriate location for these agents. Clearly, the advent of new agents requires standardised protocols for treating bleeding on an institutional level.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Buller, Harry R.Academic Medical Centre, Netherlands (författare)
  • Falanga, AnnaHospital Papa Giovanni XXIII, Italy; Hospital Papa Giovanni XXIII, Italy (författare)
  • Hacke, WernerHeidelberg University, Germany (författare)
  • Hendriks, JeroenLinköpings universitet,Avdelningen för omvårdnad,Medicinska fakulteten,University of Adelaide, Australia(Swepub:liu)jerhe83 (författare)
  • Lobban, TrudieArrhythmia Alliance and AF Assoc, England (författare)
  • Merino, JoseUniversity of La Paz, Spain (författare)
  • Milojevic, Ivan S.Gen Hospital Cuprija, Serbia (författare)
  • Moya, FranciscoVithas Xanit Int Hospital, Spain (författare)
  • Bart van der Worp, H.University of Medical Centre Utrecht, Netherlands (författare)
  • Randall, GarySAFE, England (författare)
  • Tsioufis, KonstantinosUniversity of Athens, Greece (författare)
  • Verhamme, PeterUniversity of Leuven, Belgium (författare)
  • John Camm, A.St Georges University of London, England; Imperial Coll, England (författare)
  • University of Insubria, ItalyAcademic Medical Centre, Netherlands (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Thrombosis and Haemostasis: SCHATTAUER GMBH-VERLAG MEDIZIN NATURWISSENSCHAFTEN116:6, s. 1003-10100340-62452567-689X

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