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Surgical treatment ...
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Sternby Eilard, MalinSahlgrens University Hospital, Sweden
(author)
Surgical treatment for gallbladder cancer - a systematic literature review
- Article/chapterEnglish2017
Publisher, publication year, extent ...
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2017-02-09
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TAYLOR & FRANCIS LTD,2017
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:liu-136232
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-136232URI
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https://doi.org/10.1080/00365521.2017.1284895DOI
Supplementary language notes
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Language:English
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Summary in:English
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Classification
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Subject category:ref swepub-contenttype
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Subject category:for swepub-publicationtype
Notes
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Funding Agencies|HTA - centrum in Region Vastra Gotaland in Sweden
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Objective: To evaluate existing evidence regarding surgical treatments for gallbladder cancer in a Health Technology Assessment. A specific aim was to evaluate whether extended surgery regarding liver, lymph nodes, bile duct, and adjacent organs compared with cholecystectomy alone in the adult patient with gallbladder cancer in early and late stages implies improved survival. Methods: In April 2015 and updated in June 2016, a systematic literature search was conducted in PubMed, Embase, and the Cochrane Library. Two authors independently screened titles, abstracts, and full-text articles. The certainty of evidence was evaluated according to GRADE. Main results: Forty-four observational studies (non-randomised, controlled studies) and seven case series were included. Radical resection, including liver and lymph node resection, compared with cholecystectomy alone showed significantly better survival for patients with stages T1b and above. All studies had serious study limitations and the certainty of evidence was very low (GRADE circle plus(ooo)). A survival benefit seen in patients with stage T1b or higher with lymph node resection, was most evident in stage T2, but the certainty of evidence was low (GRADE circle plus circle plus(oo)). It is uncertain whether routine bile duct resections improve overall survival in patients with gallbladder cancer stage T2-T4 (GRADE circle plus(ooo)). Conclusion: Data indicate that prognosis can be improved if liver resection and lymph node resection is performed in patients with tumour stage T1b or higher. There is no evidence supporting resection of the bile duct or adjacent organs if it is not necessary in order to achieve radicality.
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Added entries (persons, corporate bodies, meetings, titles ...)
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Lundgren, LindaRyhov Hospital, Sweden
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Cahlin, ChristianSahlgrens University Hospital, Sweden
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Strandell, AnnikaSahlgrens University Hospital, Sweden
(author)
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Svanberg, ThereseSahlgrens University Hospital, Sweden
(author)
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Sandström, Per A,1965-Linköpings universitet,Medicinska fakulteten,Avdelningen för Kirurgi, Ortopedi och Onkologi,Region Östergötland, Kirurgiska kliniken US(Swepub:liu)persa07
(author)
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Sahlgrens University Hospital, SwedenRyhov Hospital, Sweden
(creator_code:org_t)
Related titles
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In:Scandinavian Journal of Gastroenterology: TAYLOR & FRANCIS LTD52:5, s. 505-5140036-55211502-7708
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