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GAD-specific T cell...
GAD-specific T cells are induced by GAD-alum treatment in Type-1 diabetes patients
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- Pihl, Mikael (author)
- Linköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Medicinska fakulteten
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- Barcenilla, Hugo (author)
- Linköpings universitet,Avdelningen för kliniska vetenskaper,Medicinska fakulteten
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- Axelsson Chéramy, Stina (author)
- Linköpings universitet,Avdelningen för kliniska vetenskaper,Medicinska fakulteten
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- Chéramy, Mikael (author)
- Linköpings universitet,Avdelningen för kliniska vetenskaper,Medicinska fakulteten
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- Åkerman, Linda (author)
- Linköpings universitet,Avdelningen för barns och kvinnors hälsa,Medicinska fakulteten
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- Johansson, Ingela (author)
- Linköpings universitet,Avdelningen för barns och kvinnors hälsa,Medicinska fakulteten
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- Ludvigsson, Johnny (author)
- Linköpings universitet,Avdelningen för barns och kvinnors hälsa,Medicinska fakulteten,Region Östergötland, Barn- och ungdomskliniken i Linköping
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- Casas, Rosaura (author)
- Linköpings universitet,Avdelningen för barns och kvinnors hälsa,Medicinska fakulteten
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(creator_code:org_t)
- ACADEMIC PRESS INC ELSEVIER SCIENCE, 2017
- 2017
- English.
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In: Clinical Immunology. - : ACADEMIC PRESS INC ELSEVIER SCIENCE. - 1521-6616 .- 1521-7035. ; 176, s. 114-121
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Administration of Glutamic Acid Decarboxylase (GAD)(65) formulated in aluminium hydroxide preserved insulin secretion in a phase II trial in recent onset Type 1 Diabetes. A subsequent European phase III trial was closed at 15 months after failing to reach primary endpoint, but the majority of the Swedish patients completed the 21 months follow-up. We studied the frequencies and phenotype of T cells, suppressive capacity of Tregs, GAD(65)-induced proliferation, and frequencies of T cells with a GAD(65)-specific TCR in Swedes participating in the trial. Stimulation with GAD(65) induced activated T cells and also cells with a suppressive phenotype. Activated GAD(65)-specific effector T cells were detected by tetramer staining while the frequency of GAD(65)-specific Treg was not affected by the treatment. Additional doses of GAD-alum increased frequencies of CD25(+)CD127(+), but had no effect on CD25(hi)CD127(lo). Our findings indicate that GAD-alum treatment primarily induced activated T cells. GAD(65)-specific cells were mainly of activated phenotype. (C) 2017 Elsevier Inc. All rights reserved.
Subject headings
- NATURVETENSKAP -- Biologi -- Immunologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Immunology (hsv//eng)
Keyword
- Type 1 diabetes; Regulatory T cells; Immune intervention; GAD; Children
Publication and Content Type
- ref (subject category)
- art (subject category)
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