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Some Synonymous and Nonsynonymous gyrA Mutations in Mycobacterium tuberculosis Lead to Systematic False-Positive Fluoroquinolone Resistance Results with the Hain GenoType MTBDRsl Assays

Ajileye, Adebisi (author)
Birmingham Heartlands Hospital, England
Alvarez, Nataly (author)
Corp Invest Biol, Colombia; University of Pontificia Bolivariana, Colombia
Merker, Matthias (author)
Research Centre Borstel, Germany; German Centre Infect Research, Germany
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Walker, Timothy M. (author)
University of Oxford, England
Akter, Suriya (author)
Institute Trop Med, Belgium
Brown, Kerstin (author)
Birmingham Heartlands Hospital, England
Moradigaravand, Danesh (author)
Wellcome Trust Sanger Institute, England
Schön, Thomas (author)
Linköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Medicinska fakulteten,Kalmar County Hospital, Sweden
Andres, Soenke (author)
Research Centre Borstel, Germany
Schleusener, Viola (author)
Research Centre Borstel, Germany
Omar, Shaheed V. (author)
Centre TB, South Africa
Coll, Francesc (author)
London School Hyg and Trop Med, England
Huang, Hairong (author)
Capital Medical University, Peoples R China
Diel, Roland (author)
University Hospital, Germany
Ismail, Nazir (author)
Centre TB, South Africa
Parkhill, Julian (author)
Wellcome Trust Sanger Institute, Hinxton, United Kingdom
de Jong, Bouke C. (author)
Institute Trop Med, Belgium
Peto, Tim E. A. (author)
University of Oxford, England
Crook, Derrick W. (author)
University of Oxford, England; Public Health England Microbiol Serv, England
Niemann, Stefan (author)
Research Centre Borstel, Germany; German Centre Infect Research, Germany
Robledo, Jaime (author)
Corp Invest Biol, Colombia; University of Pontificia Bolivariana, Colombia
Grace Smith, E. (author)
Birmingham Heartlands Hospital, England
Peacock, Sharon J. (author)
Wellcome Trust Sanger Institute, England; London School Hyg and Trop Med, England; University of Cambridge, England
Koeser, Claudio U. (author)
University of Cambridge, England
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 (creator_code:org_t)
AMER SOC MICROBIOLOGY, 2017
2017
English.
In: Antimicrobial Agents and Chemotherapy. - : AMER SOC MICROBIOLOGY. - 0066-4804 .- 1098-6596. ; 61:4
Related links:
https://liu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
https://doi.org/10.1...
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • In this study, using the Hain GenoType MTBDRsl assays (versions 1 and 2), we found that some nonsynonymous and synonymous mutations in gyrA in Mycobacterium tuberculosis result in systematic false-resistance results to fluoroquinolones by preventing the binding of wild-type probes. Moreover, such mutations can prevent the binding of mutant probes designed for the identification of specific resistance mutations. Although these mutations are likely rare globally, they occur in approximately 7% of multidrug-resistant tuberculosis strains in some settings.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Microbiology in the medical area (hsv//eng)

Keyword

Mycobacterium tuberculosis; Hain GenoType MTBDRsl; fluoroquinolones

Publication and Content Type

ref (subject category)
art (subject category)

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