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Successful treatmen...
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Machaczka, MaciejKarolinska Institutet
(author)
Successful treatment of recurrent malignancy-associated hemophagocytic lymphohistiocytosis with a modified HLH-94 immunochemotherapy and allogeneic stem cell transplantation
- Article/chapterEnglish2012
Publisher, publication year, extent ...
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2011-04-29
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Springer Science and Business Media LLC,2012
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-233792
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-233792URI
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https://doi.org/10.1007/s12032-011-9963-3DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:124588242URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Acquired hemophagocytic lymphohistiocytosis (HLH) triggered by a known or still to be recognized malignancy is a life-threatening hyperinflammatory syndrome due to massive cytokine release from activated lymphocytes and macrophages. Malignancy-associated HLH (M-HLH) often impedes adequate treatment of malignancy and has the worst outcome compared with any other form of HLH. The incidence of M-HLH is unknown, and there are no published treatment recommendations addressed to this HLH form. Here, we report the case of a young woman with recurrent ALK1-positive anaplastic large T-cell lymphoma and M-HLH successfully treated with a modified HLH-94 protocol, allogeneic stem cell transplantation (alloSCT) and donor lymphocyte infusion (DLI). More than 3 years after DLI, the patient is alive, in complete remission from her malignancy and HLH-free, although suffering from extensive chronic graft-versus-host disease. AlloSCT and, if needed, DLI performed to consolidate remission of malignancy and HLH may have a curative impact on both entities. We propose that when discussing possible treatment options for patients with M-HLH, alloSCT should be considered in eligible individuals.
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Nahi, HarethKarolinska Institutet
(author)
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Karbach, Holger
(author)
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Klimkowska, Monika
(author)
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Hägglund, HansHematology Center Karolinska, Karolinska University Hospital Huddinge, Stockholm, Sweden
(author)
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Karolinska InstitutetHematology Center Karolinska, Karolinska University Hospital Huddinge, Stockholm, Sweden
(creator_code:org_t)
Related titles
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In:Medical Oncology: Springer Science and Business Media LLC29:2, s. 1231-12361357-05601559-131X
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