Search: id:"swepub:oai:DiVA.org:liu-13894" >
Reduced anti-TNFα a...
-
Sjöwall, ChristofferÖstergötlands Läns Landsting,Linköpings universitet,Reumatologi,Hälsouniversitetet,Länskliniken för Reumatologi i Östergötland
(author)
Reduced anti-TNFα autoantibody levels coincide with flare in systemic lupus erythematosus
- Article/chapterEnglish2004
Publisher, publication year, extent ...
-
Elsevier BV,2004
-
printrdacarrier
Numbers
-
LIBRIS-ID:oai:DiVA.org:liu-13894
-
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-13894URI
-
https://doi.org/10.1016/j.jaut.2004.02.003DOI
-
https://lup.lub.lu.se/record/1129777URI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
Deviating cytokine patterns, as a consequence of aberrant immunoregulation, is implicated to be of aetiopathogenetic importance in systemic lupus erythematosus (SLE). To evaluate the possibility of anti-cytokine autoantibody-mediated cytokine regulation/dysregulation, IgG class autoantibodies against cytokines (IL-1β, IL-6, IL-10, TNFα and TGFβ1) were analysed by enzyme-linked immunosorbent assay (ELISA) in serial serum samples from clinically well-characterized SLE patients and in normal human sera (NHS). Anti-TNFα autoantibody levels were lower in patients with active disease compared to inactive disease (P<0.001) as well as to NHS (P<0.001). The anti-TNFα antibody levels correlated inversely to the SLE disease activity index (SLEDAI) (r2=0.07, P<0.01), whereas anti-TGFβ antibodies were raised in SLE and correlated positively to levels of complement factor C1q (r2=0.08, P<0.005). Generally raised anti-cytokine antibody levels and correlations to disease activity measures were found in one individual. Inverse correlations were found comparing SLEDAI scores and autoantibodies to TNFα (r2=0.92) and IL-6 (r2=0.86) and positive correlations were found between levels of anti-TNFα and C1q (r2=0.86) and C3 (r2=0.90). We show, for the first time, a coincidence between reduced anti-TNFα autoantibody levels and disease exacerbation in SLE, which is of interest regarding aetiopathogenesis and disease control.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Ernerudh, JanLinköpings universitet,Klinisk immunologi,Hälsouniversitetet(Swepub:liu)janer15
(author)
-
Bengtsson, AndersLund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Department of Rheumatology, Lund University Hospital, Lund, Sweden(Swepub:lu)reum-abe
(author)
-
Sturfelt, GunnarLund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Department of Rheumatology, Lund University Hospital, Lund, Sweden(Swepub:lu)reum-gst
(author)
-
Skogh, ThomasÖstergötlands Läns Landsting,Linköpings universitet,Reumatologi,Hälsouniversitetet,Länskliniken för Reumatologi i Östergötland(Swepub:liu)thosk00
(author)
-
Linköpings universitetReumatologi
(creator_code:org_t)
Related titles
-
In:Journal of Autoimmunity: Elsevier BV22:4, s. 315-3230896-8411
Internet link
Find in a library
To the university's database