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The Global ECT-MRI ...
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Oltedal, LeifUniversity of Bergen, Norway; University of Calif San Diego, CA 92037 USA; University of Calif San Diego, CA 92093 USA; Haukeland Hospital, Norway
(author)
The Global ECT-MRI Research Collaboration (GEMRIC): Establishing a multi-site investigation of the neural mechanisms underlying response to electroconvulsive therapy
- Article/chapterEnglish2017
Publisher, publication year, extent ...
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ELSEVIER SCI LTD,2017
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:liu-139647
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-139647URI
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https://doi.org/10.1016/j.nicl.2017.02.009DOI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Funding Agencies|Western Norway Regional Health Authority; Haukeland University Hospital; University of Bergen, Norway; Lundbeck Foundation; German Research Foundation (DFG) [FOR2107, 1151/5-1]; Innovative Medizinische Forschung (IMF) [RE111604]; Centers of Biomedical Research Excellence [2P20GM103472-01]; Swiss National Science Foundation (NCCR Synapsy) [32003B_159780]; Foundation Parkinson Switzerland; Foundation Synapsis; Roger de Spoelberch Foundation; National Institute of Mental Health [R01MH092301, K24MH102743]; Partridge Foundation
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Major depression, currently the worlds primary cause of disability, leads to profound personal suffering and increased risk of suicide. Unfortunately, the success of antidepressant treatment varies amongst individuals and can take weeks to months in those who respond. Electroconvulsive therapy (ECT), generally prescribed for the most severely depressed and when standard treatments fail, produces a more rapid response and remains the most effective intervention for severe depression. Exploring the neurobiological effects of ECT is thus an ideal approach to better understand the mechanisms of successful therapeutic response. Though several recent neuroimaging studies show structural and functional changes associated with ECT, not all brain changes associate with clinical outcome. Larger studies that can address individual differences in clinical and treatment parameters may better target biological factors relating to or predictive of ECT-related therapeutic response. We have thus formed the Global ECT-MRI Research Collaboration (GEMRIC) that aims to combine longitudinal neuroimaging as well as clinical, behavioral and other physiological data across multiple independent sites. Here, we summarize the ECT sample characteristics from currently participating sites, and the common data-repository and standardized image analysis pipeline developed for this initiative. This includes data harmonization across sites and MRI platforms, and a method for obtaining unbiased estimates of structural change based on longitudinal measurements with serial MRI scans. The optimized analysis pipeline, together with the large and heterogeneous combined GEMRIC dataset, will provide new opportunities to elucidate the mechanisms of ECT response and the factors mediating and predictive of clinical outcomes, which may ultimately lead to more effective personalized treatment approaches. (C) 2017 The Author(s). Published by Elsevier Inc.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Bartsch, HaukeUniversity of Calif San Diego, CA 92037 USA; University of Calif San Diego, CA 92093 USA
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Evjenth Sorhaug, Ole JohanUniversity of Bergen, Norway
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Kessler, UteUniversity of Bergen, Norway; Haukeland Hospital, Norway
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Abbott, ChristopherUniversity of New Mexico, NM 87131 USA
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Dols, AnnemiekeVUmc Amsterdam, Netherlands
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Stek, Max L.VUmc Amsterdam, Netherlands
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Ersland, LarsHaukeland Hospital, Norway
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Emsell, LouiseKatholieke University of Leuven, Belgium
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van Eijndhoven, PhilipDonders Institute Brain Cognit and Behav, Netherlands
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Argyelan, MiklosFeinstein Institute Medical Research, NY USA
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Tendolkar, IndiraDonders Institute Brain Cognit and Behav, Netherlands
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Nordanskog, Pia,1971-Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten,Region Östergötland, Psykiatriska kliniken(Swepub:liu)piano33
(author)
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Hamilton, Paul J.,1970-Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten(Swepub:liu)pauha77
(author)
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Balslev Jorgensen, MartinPsychiat Centre Copenhagen, Denmark
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Sommer, Iris E.University of Medical Centre, Netherlands
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Heringa, Sophie M.University of Medical Centre, Netherlands
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Draganski, BogdanUniversity of Lausanne, Switzerland; Max Planck Institute Human Brain and Cognit Neurosci, Germany
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Redlich, RonnyDepartment of Psychiatry, University of Münster, Germany
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Dannlowski, UdoUniversity of Munster, Germany; University of Marburg, Germany
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Kugel, HaraldUniversity of Munster, Germany
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Bouckaert, FilipKatholieke University of Leuven, Belgium
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Sienaert, PascalKatholieke University of Leuven, Belgium
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Anand, AmitCleveland Clin, OH 44106 USA
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Espinoza, RandallUniversity of Calif Los Angeles, CA USA
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Narr, Katherine L.University of Calif Los Angeles, CA 90024 USA
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Holland, DominicUniversity of Calif San Diego, CA 92037 USA; University of Calif San Diego, CA 92093 USA
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Dale, Anders M.University of Calif San Diego, CA 92037 USA; University of Calif San Diego, CA 92093 USA; University of Calif San Diego, CA 92093 USA
(author)
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Oedegaard, Ketil J.University of Bergen, Norway; Haukeland Hospital, Norway; KG Jebsen Centre Research Neuropsychiat Disorders, Norway
(author)
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University of Bergen, Norway; University of Calif San Diego, CA 92037 USA; University of Calif San Diego, CA 92093 USA; Haukeland Hospital, NorwayUniversity of Calif San Diego, CA 92037 USA; University of Calif San Diego, CA 92093 USA
(creator_code:org_t)
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In:NeuroImage: ELSEVIER SCI LTD14, s. 422-4322213-1582
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Oltedal, Leif
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Bartsch, Hauke
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Evjenth Sorhaug, ...
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Kessler, Ute
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Abbott, Christop ...
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Dols, Annemieke
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Stek, Max L.
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Ersland, Lars
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Emsell, Louise
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Argyelan, Miklos
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Tendolkar, Indir ...
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Nordanskog, Pia, ...
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Hamilton, Paul J ...
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Balslev Jorgense ...
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Sommer, Iris E.
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Heringa, Sophie ...
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Draganski, Bogda ...
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Redlich, Ronny
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Dannlowski, Udo
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Kugel, Harald
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Bouckaert, Filip
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Sienaert, Pascal
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Anand, Amit
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Holland, Dominic
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Dale, Anders M.
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