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JAM-A regulates epithelial proliferation through Akt/beta-catenin signalling

Nava, Porfirio (författare)
Epithelial Pathobiology Research Unit, Department of Pathology, Emory University, Whitehead Biomedical Research Building, Atlanta, Georgia, USA
Capaldo, Christopher T. (författare)
Epithelial Pathobiology Research Unit, Department of Pathology, Emory University, Whitehead Biomedical Research Building, Atlanta, Georgia, USA
Koch, Stefan (författare)
Epithelial Pathobiology Research Unit, Department of Pathology, Emory University, Whitehead Biomedical Research Building, Atlanta, Georgia, USA
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Kolegraff, Keli (författare)
Epithelial Pathobiology Research Unit, Department of Pathology, Emory University, Whitehead Biomedical Research Building, Atlanta, Georgia, USA
Rankin, Carl Robert (författare)
Epithelial Pathobiology Research Unit, Department of Pathology, Emory University, Whitehead Biomedical Research Building, Atlanta, Georgia, USA
Farkas, Attila E. (författare)
Epithelial Pathobiology Research Unit, Department of Pathology, Emory University, Whitehead Biomedical Research Building, Atlanta, Georgia, USA; Institute of Biophysics, Biological Research Center, Szeged, Hungary
Feasel, Mattie E. (författare)
Epithelial Pathobiology Research Unit, Department of Pathology, Emory University, Whitehead Biomedical Research Building, Atlanta, Georgia, USA
Li, Linheng (författare)
Stowers Institute for Medical Research, Kansas City, Missouri, USA
Addis, Caroline (författare)
Epithelial Pathobiology Research Unit, Department of Pathology, Emory University, Whitehead Biomedical Research Building, Atlanta, Georgia, USA
Parkos, Charles A. (författare)
Epithelial Pathobiology Research Unit, Department of Pathology, Emory University, Whitehead Biomedical Research Building, Atlanta, Georgia, USA
Nusrat, Asma (författare)
Epithelial Pathobiology Research Unit, Department of Pathology, Emory University, Whitehead Biomedical Research Building, Atlanta, Georgia, USA
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 (creator_code:org_t)
2011-03-04
2011
Engelska.
Ingår i: EMBO Reports. - : Wiley-Blackwell Publishing Inc.. - 1469-221X .- 1469-3178. ; 12:4, s. 314-20
Relaterad länk:
https://europepmc.or...
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https://urn.kb.se/re...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Expression of the tight junction protein junctional adhesion molecule-A (JAM-A) has been linked to proliferation and tumour progression. However, a direct role for JAM-A in regulating proliferative processes has not been shown. By using complementary in vivo and in vitro approaches, we demonstrate that JAM-A restricts intestinal epithelial cell (IEC) proliferation in a dimerization-dependent manner, by inhibiting Akt-dependent beta-catenin activation. Furthermore, IECs from transgenic JAM-A(-/-)/beta-catenin/T-cell factor reporter mice showed enhanced beta-catenin-dependent transcription. Finally, inhibition of Akt reversed colonic crypt hyperproliferation in JAM-A-deficient mice. These data establish a new link between JAM-A and IEC homeostasis.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)

Nyckelord

junctional adhesion molecule; Akt; b-catenin; cell proliferation; tight junction

Publikations- och innehållstyp

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