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Coronin 1C negative...
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Samarin, Stanislav N.Epithelial Pathobiology Research Unit, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, USA
(författare)
Coronin 1C negatively regulates cell-matrix adhesion and motility of intestinal epithelial cells
- Artikel/kapitelEngelska2010
Förlag, utgivningsår, omfång ...
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Elsevier,2010
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:liu-141668
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-141668URI
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https://doi.org/10.1016/j.bbrc.2009.11.069DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Samarin, Stanislav N Koch, Stefan Ivanov, Andrei I Parkos, Charles A Nusrat, Asma eng R01 DK059888-09/DK/NIDDK NIH HHS/ R01 DK061379-08/DK/NIDDK NIH HHS/ R29 DK055679/DK/NIDDK NIH HHS/ DK 55679/DK/NIDDK NIH HHS/ DK 064399/DK/NIDDK NIH HHS/ DK 61379/DK/NIDDK NIH HHS/ R01 DK072564/DK/NIDDK NIH HHS/ DK 72564/DK/NIDDK NIH HHS/ R24 DK064399/DK/NIDDK NIH HHS/ R01 DK055679-11A1/DK/NIDDK NIH HHS/ R24 DK064399-019003/DK/NIDDK NIH HHS/ R01 DK055679/DK/NIDDK NIH HHS/ DK 59888/DK/NIDDK NIH HHS/ R01 DK061379/DK/NIDDK NIH HHS/ R01 DK059888/DK/NIDDK NIH HHS/ R01 DK072564-15/DK/NIDDK NIH HHS/ Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't 2009/11/17 06:00 Biochem Biophys Res Commun. 2010 Jan 1;391(1):394-400. doi: 10.1016/j.bbrc.2009.11.069. Epub 2009 Nov 12.
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Coronins, WD-repeat actin-binding proteins, are known to regulate cell motility by coordinating actin filament turnover in lamellipodia of migrating cell. Here we report a novel mechanism of Coronin 1C-mediated cell motility that involves regulation of cell-matrix adhesion. RNAi silencing of Coronin 1C in intestinal epithelial cells enhanced cell migration and modulated lamellipodia dynamics by increasing the persistence of lamellipodial protrusion. Coronin 1C-depleted cells showed increased cell-matrix adhesions and enhanced cell spreading compared to control cells, while over-expression of Coronin 1C antagonized cell adhesion and spreading. Enhanced cell-matrix adhesion of coronin-deficient cells correlated with hyperphosphorylation of focal adhesion kinase (FAK) and paxillin, and an increase in number of focal adhesions and their redistribution at the cell periphery. siRNA depletion of FAK in coronin-deficient cells rescued the effects of Coronin 1C depletion on motility, cell-matrix adhesion, and spreading. Thus, our findings provide the first evidence that Coronin 1C negatively regulates epithelial cell migration via FAK-mediated inhibition of cell-matrix adhesion.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Koch, StefanLinköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Medicinska fakulteten,Epithelial Pathobiology Research Unit, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, USA(Swepub:liu)steko54
(författare)
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Ivanov, Andrei I.Department of Medicine, University of Rochester, Rochester, NY, USA
(författare)
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Parkos, Charles A.Epithelial Pathobiology Research Unit, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, USA
(författare)
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Nusrat, AsmaEpithelial Pathobiology Research Unit, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, USA
(författare)
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Epithelial Pathobiology Research Unit, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, USAAvdelningen för mikrobiologi och molekylär medicin
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Biochemical and Biophysical Research Communications - BBRC: Elsevier391:1, s. 394-4000006-291X1090-2104
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