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Protective Effects ...
Protective Effects of Oral Astaxanthin Nanopowder against Ultraviolet-Induced Photokeratitis in Mice
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- Harada, Fumiya (författare)
- Health Science University of Hokkaido, Japan; Taipei Medical University, Taiwan
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- Morikawa, Tetsuro (författare)
- Health Science University of Hokkaido, Japan
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- Lennikov, Anton (författare)
- Linköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Far Eastern Federal University, Russia
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- Mukwaya, Anthony (författare)
- Linköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten
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- Schaupper, Mira (författare)
- Linköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten
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- Uehara, Osamu (författare)
- Health Science University of Hokkaido, Japan
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- Takai, Rie (författare)
- Health Science University of Hokkaido, Japan
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- Yoshida, Koki (författare)
- Health Science University of Hokkaido, Japan
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- Sato, Jun (författare)
- Health Science University of Hokkaido, Japan
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- Horie, Yukihiro (författare)
- Hokkaido University, Japan
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- Sakaguchi, Hiroyuki (författare)
- FUJIFILM Corp, Japan
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- Wu, Ching-Zong (författare)
- Taipei Medical University Hospital, Taiwan; Lotung Poh Ai Hospital, Taiwan
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- Abiko, Yoshihiro (författare)
- Health Science University of Hokkaido, Japan
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- Lagali, Neil (författare)
- Linköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Region Östergötland, Ögonkliniken US
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- Kitaichi, Nobuyoshi (författare)
- Hokkaido University, Japan; Health Science University of Hokkaido Hospital, Japan
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(creator_code:org_t)
- HINDAWI LTD, 2017
- 2017
- Engelska.
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Ingår i: Oxidative Medicine and Cellular Longevity. - : HINDAWI LTD. - 1942-0900 .- 1942-0994.
- Relaterad länk:
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https://liu.diva-por... (primary) (Raw object)
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http://downloads.hin...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Purpose. Astaxanthin (AST) has a strong antioxidant cellular membrane chaperone protective effect. Recently, a water-soluble nanosized AST (nano-AST) form was produced, which is expected to improve the efficacy of oral intake effects. The purpose of this study was to examine whether oral nano-AST has therapeutic effects on UV-induced photokeratitis in mice. Methods. C57BL/6 mice were administered twice with either nano-AST, AST oil, lutein, or bilberry extracts 3 hours before and shortly before UV irradiation (dose: 400 mJ/cm2). The corneas were collected 24 hours after irradiation and stained with Hamp;E and TUNEL. NF-kappa B, dihydroethidium (DHE), COX-2, p-I kappa B-alpha, TNF alpha, and CD45 expression were evaluated through immunohistochemistry, Western blot analysis, and qPCR. Results. Corneal epithelium was significantly thicker in mice orally administered with nano-AST than in the others (p amp;lt; 0.01), with significantly less NF-kappa B nucleus translocation (p amp;lt; 0.001), and significantly fewer TUNEL cells (p amp;lt; 0.01). Weaker DHE signals were detected in the nano-AST group (p amp;lt; 0.05) relative to the others. Furthermore, reduced inflammation and decreased cell death in corneal tissue were observed in the nano-AST group, as indicated by a reduction in the expression of COX-2, p-I kappa B-alpha, TNFa, and CD45. Conclusions. Oral administration of nano-AST demonstrated a protective effect on UV-induced photokeratitis via antioxidative, anti-inflammatory, and antiapoptotic activity.
Ämnesord
- NATURVETENSKAP -- Biologi -- Immunologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Immunology (hsv//eng)
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- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Harada, Fumiya
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Morikawa, Tetsur ...
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Lennikov, Anton
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Mukwaya, Anthony
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Schaupper, Mira
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Uehara, Osamu
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Takai, Rie
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Yoshida, Koki
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Sato, Jun
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Horie, Yukihiro
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Sakaguchi, Hiroy ...
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Wu, Ching-Zong
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Abiko, Yoshihiro
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Lagali, Neil
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Kitaichi, Nobuyo ...
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- Om ämnet
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- NATURVETENSKAP
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NATURVETENSKAP
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och Biologi
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och Immunologi
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Oxidative Medici ...
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Linköpings universitet