Search: WFRF:(Georgakis Marios K.)
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Malignant Central N...
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Georgakis, Marios K.University of Athens, Greece
(author)
Malignant Central Nervous System Tumors Among Adolescents and Young Adults (15-39 Years Old) in 14 Southern-Eastern European Registries and the US Surveillance, Epidemiology, and End Results Program: Mortality and Survival Patterns
- Article/chapterEnglish2017
Publisher, publication year, extent ...
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2017-07-14
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WILEY,2017
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:liu-143069
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-143069URI
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https://doi.org/10.1002/cncr.30884DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:136966905URI
Supplementary language notes
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Language:English
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Summary in:English
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Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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BACKGROUND: Unique features and worse outcomes have been reported for cancers among adolescents and young adults (AYAs; 15-39 years old). The aim of this study was to explore the mortality and survival patterns of malignant central nervous system (CNS) tumors among AYAs in Southern-Eastern Europe (SEE) in comparison with the US Surveillance, Epidemiology, and End Results (SEER) program. METHODS: Malignant CNS tumors diagnosed in AYAs during the period spanning 1990-2014 were retrieved from 14 population-based cancer registries in the SEE region (n = 11,438). Age-adjusted mortality rates were calculated and survival patterns were evaluated via Kaplan-Meier curves and Cox regression analyses, and they were compared with respective 1990-2012 figures from SEER (n = 13,573). RESULTS: Mortality rates in SEE (range, 11.9-18.5 deaths per million) were higher overall than the SEER rate (9.4 deaths per million), with decreasing trends in both regions. Survival rates increased during a comparable period (2001-2009) in SEE and SEER. The 5-year survival rate was considerably lower in the SEE registries (46%) versus SEER (67%), mainly because of the extremely low rates in Ukraine; this finding was consistent across age groups and diagnostic subtypes. The highest 5-year survival rates were recorded for ependymomas (76% in SEE and 92% in SEER), and the worst were recorded for glioblastomas and anaplastic astrocytomas (28% in SEE and 37% in SEER). Advancing age, male sex, and rural residency at diagnosis adversely affected outcomes in both regions. CONCLUSIONS: Despite definite survival gains over the last years, the considerable outcome disparities between the less affluent SEE region and the United States for AYAs with malignant CNS tumors point to health care delivery inequalities. No considerable prognostic deficits for CNS tumors are evident for AYAs versus children. (c) 2017 American Cancer Society.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Papathoma, ParaskeviRegion Östergötland, Neurologiska kliniken i Linköping,University of Athens, Greece
(author)
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Ryzhov, AntonNational Cancer Registry Ukraine, Ukraine
(author)
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Zivkovic-Perisic, SnezanaInstitute Public Health Serbia, Serbia
(author)
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Eser, SultanIzmir and Hacettepe University, Turkey
(author)
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Taraszkiewicz, LukaszGreater Poland Cancer Centre, Poland
(author)
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Sekerija, MarioCroatian Institute Public Heatlh, Croatia
(author)
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Zagar, TinaCancer Registry Republ Slovenia, Slovenia
(author)
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Antunes, LuisPortuguese Oncology Institute Porto, Portugal
(author)
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Zborovskaya, AnnaBelarusian Research Center for Pediatric Oncology, Hematology, and Immunology, Childhood Cancer Subregistry of Belarus, Minsk, Belarus
(author)
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Bastos, JoanaPortuguese Oncology Institute Coimbra, Portugal
(author)
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Florea, MargaretaNational Institute Public Heatlh, Romania
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Coza, DanielaIon Chiricuta Oncology Institute, Romania
(author)
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Demetriou, AnnaChildhood Cancer Subregistry Belarus, Byelarus; Minist Heatlh, Cyprus
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Agius, DomenicMalta National Cancer Registry, Malta
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Strahinja, Rajko M.Institute Public Heatlh, Montenegro
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Themistocleous, MariosAghia Sophia Childrens Hospital, Greece
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Tolia, MariaUniversity of Athens, Greece
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Tzanis, SpyridonErrikos Dunant Hospital Centre, Greece
(author)
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Alexiou, George A.Ioannina University, Greece
(author)
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Papanikolaou, Panagiotis G.Gen Nikaia Piraeus Hospital, Greece
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Nomikos, PanagiotisHygeia Hospital, Greece
(author)
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Kantzanou, MariaUniversity of Athens, Greece
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Dessypris, NickUniversity of Athens, Greece
(author)
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Pourtsidis, ApostolosPanagiotis and Aglaia Kyriakou Childrens Hospital, Greece
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Petridou, Eleni T.University of Athens, Greece; Karolinska Institute, Sweden
(author)
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University of Athens, GreeceRegion Östergötland, Neurologiska kliniken i Linköping
(creator_code:org_t)
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In:Cancer: WILEY123:22, s. 4458-44710008-543X1097-0142
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Sekerija, Mario
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