Expression of low-density lipoprotein-related receptors 5 and 6 (LRP5/6) in psoriasis skin

Funding Agencies|Futurum - Academy for Health and Care, Region Jonkoping County, Sweden; Swedish Psoriasis Foundation
Low-density lipoprotein-related receptors 5 and 6 (LRP5/6) are transmembrane receptors with key functions in canonical Wnt signalling. Wnt ligands are thought to play an important role in innate immunity and psoriasis, and recent studies assigned LRP5/6 anti-inflammatory properties. The objective of this study was to investigate the expression of LRP5 and LRP6 in lesional and non-lesional skin in peripheral blood and in mononuclear cells of patients with chronic plaque type psoriasis compared with control individuals. To investigate the effect of UV-B radiation, LRP5/6 skin gene expression was analysed before and after narrowband UV-B treatment. Our results showed significantly decreased gene expression of LRP5 and LRP6 in lesional skin and in peripheral blood from patients with psoriasis compared with non-lesional skin and healthy control skin. Immunohistochemistry did not reveal differences in protein expression of LRP5/6. Narrowband UV-B treatment induced a significant increase in LRP5 and LRP6 gene expression in lesional skin. Decreased gene expression of LRP5/6 in lesional skin and upregulation after nb UV-B treatment suggest a possible role for LRP5/6 in psoriasis.

Slind Olsen, RenateKarolinska Institutet,Linköpings universitet,Avdelningen för läkemedelsforskning,Medicinska fakulteten,Regional Jonköping County, Sweden(Swepub:liu)rensl63 (författare)
Nyström, HelenaRegional Jonköping County, Sweden (författare)
Skarstedt, MaritaRegional Jonköping County, Sweden (författare)
Dienus, OlafRegional Jonköping County, Sweden (författare)
Mrowietz, UlrichUniversity of Medical Centre Schleswig Holstein, Germany (författare)
Soederman, JanRegional Jonköping County, Sweden (författare)
Seifert, OliverLinköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten,Regional Jonköping County, Sweden(Swepub:liu)olise96 (författare)
Regional Jönköping County, SwedenAvdelningen för läkemedelsforskning (creator_code:org_t)

Av författaren/redakt...: Duvetorp, Albert; Slind Olsen, Ren ...; Nyström, Helena; Skarstedt, Marit ...; Dienus, Olaf; Mrowietz, Ulrich; visa fler...; Soederman, Jan; Seifert, Oliver; visa färre...

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