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Expression of low-d...
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Duvetorp, AlbertRegional Jönköping County, Sweden
(författare)
Expression of low-density lipoprotein-related receptors 5 and 6 (LRP5/6) in psoriasis skin
- Artikel/kapitelEngelska2017
Förlag, utgivningsår, omfång ...
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2017-07-09
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WILEY,2017
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:liu-143088
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-143088URI
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https://doi.org/10.1111/exd.13362DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:136922796URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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Funding Agencies|Futurum - Academy for Health and Care, Region Jonkoping County, Sweden; Swedish Psoriasis Foundation
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Low-density lipoprotein-related receptors 5 and 6 (LRP5/6) are transmembrane receptors with key functions in canonical Wnt signalling. Wnt ligands are thought to play an important role in innate immunity and psoriasis, and recent studies assigned LRP5/6 anti-inflammatory properties. The objective of this study was to investigate the expression of LRP5 and LRP6 in lesional and non-lesional skin in peripheral blood and in mononuclear cells of patients with chronic plaque type psoriasis compared with control individuals. To investigate the effect of UV-B radiation, LRP5/6 skin gene expression was analysed before and after narrowband UV-B treatment. Our results showed significantly decreased gene expression of LRP5 and LRP6 in lesional skin and in peripheral blood from patients with psoriasis compared with non-lesional skin and healthy control skin. Immunohistochemistry did not reveal differences in protein expression of LRP5/6. Narrowband UV-B treatment induced a significant increase in LRP5 and LRP6 gene expression in lesional skin. Decreased gene expression of LRP5/6 in lesional skin and upregulation after nb UV-B treatment suggest a possible role for LRP5/6 in psoriasis.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Slind Olsen, RenateKarolinska Institutet,Linköpings universitet,Avdelningen för läkemedelsforskning,Medicinska fakulteten,Regional Jonköping County, Sweden(Swepub:liu)rensl63
(författare)
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Nyström, HelenaRegional Jonköping County, Sweden
(författare)
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Skarstedt, MaritaRegional Jonköping County, Sweden
(författare)
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Dienus, OlafRegional Jonköping County, Sweden
(författare)
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Mrowietz, UlrichUniversity of Medical Centre Schleswig Holstein, Germany
(författare)
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Soederman, JanRegional Jonköping County, Sweden
(författare)
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Seifert, OliverLinköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten,Regional Jonköping County, Sweden(Swepub:liu)olise96
(författare)
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Regional Jönköping County, SwedenAvdelningen för läkemedelsforskning
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Experimental dermatology: WILEY26:11, s. 1033-10380906-67051600-0625
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