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Targeted inhibition...
Targeted inhibition of prostate cancer metastases with an RNA aptamer to prostate-specific membrane antigen
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- Dassie, Justin P. (author)
- Department of Internal Medicine, University of of Iowa, 375 Newton Rd, 5202 MERF, Iowa City, IA, United States
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- Hernandez, Luiza I. (author)
- Department of Internal Medicine, University of of Iowa, 375 Newton Rd, 5202 MERF, Iowa City, IA, United States
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- Thomas, Gregory S. (author)
- Department of Internal Medicine, University of of Iowa, 375 Newton Rd, 5202 MERF, Iowa City, IA, United States
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- Long, Matthew E. (author)
- Molecular and Cellular Biology Program, University of of Iowa, Iowa City, IA, United States; Inflammation Program, University of of Iowa, Iowa City, IA, United States
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- Rockey, William M. (author)
- Department of Radiation Oncology, University of of Iowa, Iowa City, IA, United States
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- Howell, Craig A. (author)
- Department of Internal Medicine, University of of Iowa, 375 Newton Rd, 5202 MERF, Iowa City, IA, United States
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- Chen, Yani (author)
- Department of Internal Medicine, University of of Iowa, 375 Newton Rd, 5202 MERF, Iowa City, IA, United States
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- Hernandez, Frank J (author)
- Department of Internal Medicine, University of of Iowa, 375 Newton Rd, 5202 MERF, Iowa City, IA, United States
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- Liu, Xiu Y. (author)
- Department of Internal Medicine, University of of Iowa, 375 Newton Rd, 5202 MERF, Iowa City, IA, United States
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- Wilson, Mary E. (author)
- Department of Internal Medicine, University of of Iowa, 375 Newton Rd, 5202 MERF, Iowa City, IA, United States; Department of Microbiology, University of of Iowa, Iowa City, IA, United States; Veterans Affairs Medical Center, University of of Iowa, Iowa City, IA, United States
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- Allen, Lee-Ann (author)
- Department of Internal Medicine, University of of Iowa, 375 Newton Rd, 5202 MERF, Iowa City, IA, United States; Molecular and Cellular Biology Program, University of of Iowa, Iowa City, IA, United States; Inflammation Program, University of of Iowa, Iowa City, IA, United States; Department of Microbiology, University of of Iowa, Iowa City, IA, United States; Veterans Affairs Medical Center, University of of Iowa, Iowa City, IA, United States
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- Vaena, Daniel A. (author)
- Department of Internal Medicine, University of of Iowa, 375 Newton Rd, 5202 MERF, Iowa City, IA, United States
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- Meyerholz, David K. (author)
- Department of Pathology, University of of Iowa, Iowa City, IA, United States
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- Giangrande, Paloma H. (author)
- Department of Internal Medicine, University of of Iowa, 375 Newton Rd, 5202 MERF, Iowa City, IA, United States; Molecular and Cellular Biology Program, University of of Iowa, Iowa City, IA, United States; Department of Radiation Oncology, University of of Iowa, Iowa City, IA, United States
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(creator_code:org_t)
- Nature Publishing Group, 2014
- 2014
- English.
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In: Molecular Therapy. - : Nature Publishing Group. - 1525-0016 .- 1525-0024. ; 22:11, s. 1910-1922
- Related links:
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https://doi.org/10.1...
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Abstract
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- Cell-targeted therapies (smart drugs), which selectively control cancer cell progression with limited toxicity to normal cells, have been developed to effectively treat some cancers. However, many cancers such as metastatic prostate cancer (PC) have yet to be treated with current smart drug technology. Here, we describe the thorough preclinical characterization of an RNA aptamer (A9g) that functions as a smart drug for PC by inhibiting the enzymatic activity of prostate-specific membrane antigen (PSMA). Treatment of PC cells with A9g results in reduced cell migration/invasion in culture and metastatic disease in vivo. Importantly, A9g is safe in vivo and is not immunogenic in human cells. Pharmacokinetic and biodistribution studies in mice confirm target specificity and absence of non-specific on/off-target effects. In conclusion, these studies provide new and important insights into the role of PSMA in driving carcinogenesis and demonstrate critical endpoints for the translation of a novel RNA smart drug for advanced stage PC. © The American Society of Gene amp; Cell Therapy.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
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- ref (subject category)
- art (subject category)
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- By the author/editor
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Dassie, Justin P ...
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Hernandez, Luiza ...
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Thomas, Gregory ...
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Long, Matthew E.
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Rockey, William ...
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Howell, Craig A.
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show more...
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Chen, Yani
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Hernandez, Frank ...
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Liu, Xiu Y.
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Wilson, Mary E.
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Allen, Lee-Ann
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Vaena, Daniel A.
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Meyerholz, David ...
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Giangrande, Palo ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Medical Biotechn ...
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and Medical Biotechn ...
- Articles in the publication
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Molecular Therap ...
- By the university
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Linköping University