Structural advances on titin: towards an atomic understanding of multi-domain functions in myofilament mechanics and scaffolding.

Zacharchenko, ThomasInstitute of Integrative Biology, University of Liverpool, Liverpool, United Kingdom (författare)

Structural advances on titin : towards an atomic understanding of multi-domain functions in myofilament mechanics and scaffolding.

Titin is a gigantic filamentous protein of the muscle sarcomere that plays roles in myofibril mechanics and homoeostasis. 3D-structures of multi-domain fragments of titin are now available that start revealing the molecular mechanisms governing its mechanical and scaffolding functions. This knowledge is now being translated into the fabrication of self-assembling biopolymers. Here we review the structural advances on titin, the novel concepts derived from these and the emerging translational avenues.

von Castelmur, EleonoreInstitute of Integrative Biology, University of Liverpool, Liverpool, United Kingdom, Netherlands Cancer Institute, Amsterdam, Netherlands(Swepub:liu)elevo74 (författare)
Rigden, Daniel JInstitute of Integrative Biology, University of Liverpool, Liverpool, United Kingdom (författare)
Mayans, OlgaInstitute of Integrative Biology, University of Liverpool, Liverpool, United Kingdom (författare)
Institute of Integrative Biology, University of Liverpool, Liverpool, United KingdomInstitute of Integrative Biology, University of Liverpool, Liverpool, United Kingdom, Netherlands Cancer Institute, Amsterdam, Netherlands (creator_code:org_t)

Ingår i:Biochemical Society Transactions: Portland Press Ltd43:5, s. 850-50300-51271470-8752

Av författaren/redakt...: Zacharchenko, Th ...; von Castelmur, E ...; Rigden, Daniel J; Mayans, Olga

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