Structural advances on titin : towards an atomic understanding of multi-domain functions in myofilament mechanics and scaffolding.

• Titin is a gigantic filamentous protein of the muscle sarcomere that plays roles in myofibril mechanics and homoeostasis. 3D-structures of multi-domain fragments of titin are now available that start revealing the molecular mechanisms governing its mechanical and scaffolding functions. This knowledge is now being translated into the fabrication of self-assembling biopolymers. Here we review the structural advances on titin, the novel concepts derived from these and the emerging translational avenues.

Subject headings

NATURVETENSKAP  -- Kemi (hsv//swe)

NATURAL SCIENCES  -- Chemical Sciences (hsv//eng)

Keyword

crystal structure

multi-Ig tandem

protein nanofibre

protein scaffold

titin

Publication and Content Type

ref (subject category)

art (subject category)