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Competition between...
Competition between MPS1 and microtubules at kinetochores regulates spindle checkpoint signaling
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- Hiruma, Yoshitaka (författare)
- Division of Biochemistry, Netherlands Cancer Institute, Amsterdam, Netherlands; Molecular Cancer Research, University Medical Center Utrecht, Utrecht, Netherlands; Cancer Genomics Netherlands, University Medical Center Utrecht, Utrecht, Netherlands
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- Sacristan, Carlos (författare)
- Molecular Cancer Research, University Medical Center Utrecht, Utrecht, Netherlands; Cancer Genomics Netherlands, University Medical Center Utrecht, Utrecht, Netherlands
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- Pachis, Spyridon T (författare)
- Molecular Cancer Research, University Medical Center Utrecht, Utrecht, Netherlands; Cancer Genomics Netherlands, University Medical Center Utrecht, Utrecht, Netherlands
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- Adamopoulos, Athanassios (författare)
- Division of Biochemistry, Netherlands Cancer Institute, Amsterdam, Netherlands
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- Kuijt, Timo (författare)
- Molecular Cancer Research, University Medical Center Utrecht, Utrecht, Netherlands; Cancer Genomics Netherlands, University Medical Center Utrecht, Utrecht, Netherlands
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- Ubbink, Marcellus (författare)
- Leiden Institute of Chemistry, Leiden University, Leiden, Netherlands
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- von Castelmur, Eleonore (författare)
- Division of Biochemistry, Netherlands Cancer Institute, Amsterdam, Netherlands
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- Perrakis, Anastassis (författare)
- Division of Biochemistry, Netherlands Cancer Institute, Amsterdam, Netherlands
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- Kops, Geert J P L (författare)
- Molecular Cancer Research, University Medical Center Utrecht, Utrecht, Netherlands; Cancer Genomics Netherlands, University Medical Center Utrecht, Utrecht, Netherlands
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(creator_code:org_t)
- Washington, DC, United States : American Association for the Advancement of Science (A A A S), 2015
- 2015
- Engelska.
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Ingår i: Science. - Washington, DC, United States : American Association for the Advancement of Science (A A A S). - 0036-8075 .- 1095-9203. ; 348:6240, s. 1264-1267
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Cell division progresses to anaphase only after all chromosomes are connected to spindle microtubules through kinetochores and the spindle assembly checkpoint (SAC) is satisfied. We show that the amino-terminal localization module of the SAC protein kinase MPS1 (monopolar spindle 1) directly interacts with the HEC1 (highly expressed in cancer 1) calponin homology domain in the NDC80 (nuclear division cycle 80) kinetochore complex in vitro, in a phosphorylation-dependent manner. Microtubule polymers disrupted this interaction. In cells, MPS1 binding to kinetochores or to ectopic NDC80 complexes was prevented by end-on microtubule attachment, independent of known kinetochore protein-removal mechanisms. Competition for kinetochore binding between SAC proteins and microtubules provides a direct and perhaps evolutionarily conserved way to detect a properly organized spindle ready for cell division.
Ämnesord
- NATURVETENSKAP -- Kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences (hsv//eng)
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