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Amyloid polymorphis...
Amyloid polymorphisms constitute distinct clouds of conformational variants in different etiological subtypes of Alzheimers disease
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- Rasmussen, Jay (författare)
- University of Tubingen, Germany; German Centre Neurodegenerat Disease, Germany; University of Tubingen, Germany
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- Mahler, Jasmin (författare)
- University of Tubingen, Germany
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- Beschorner, Natalie (författare)
- University of Tubingen, Germany
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- Kaeser, Stephan A. (författare)
- University of Tubingen, Germany; German Centre Neurodegenerat Disease, Germany
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- Haesler, Lisa M. (författare)
- University of Tubingen, Germany; German Centre Neurodegenerat Disease, Germany
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- Baumann, Frank (författare)
- University of Tubingen, Germany; German Centre Neurodegenerat Disease, Germany
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- Nyström, Sofie (författare)
- Linköpings universitet,Kemi,Tekniska fakulteten
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- Portelius, Erik, 1977 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Blennow, Kaj, 1958 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Lashley, Tammaryn (författare)
- UCL, England
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- Fox, Nick C. (författare)
- UCL, England
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- Sepulveda-Falla, Diego (författare)
- University of Medical Centre Hamburg Eppendorf, Germany; University of Antioquia, Colombia; University of Antioquia, Colombia
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- Glatzel, Markus (författare)
- University of Medical Centre Hamburg Eppendorf, Germany
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- Oblak, Adrian L. (författare)
- Indiana University of School Med, IN 46202 USA
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- Ghetti, Bernardino (författare)
- Indiana University of School Med, IN 46202 USA
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- Nilsson, Peter (författare)
- Linköpings universitet,Kemi,Tekniska fakulteten
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- Hammarström, Per (författare)
- Linköpings universitet,Kemi,Tekniska fakulteten
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- Staufenbiel, Matthias (författare)
- University of Tubingen, Germany
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- Walker, Lary C. (författare)
- Emory University, GA 30329 USA
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- Jucker, Mathias (författare)
- University of Tubingen, Germany; German Centre Neurodegenerat Disease, Germany
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(creator_code:org_t)
- 2017-11-20
- 2017
- Engelska.
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Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : NATL ACAD SCIENCES. - 0027-8424 .- 1091-6490. ; 114:49, s. 13018-13023
- Relaterad länk:
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https://www.pnas.org...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://gup.ub.gu.se...
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Abstract
Ämnesord
Stäng
- The molecular architecture of amyloids formed in vivo can be interrogated using luminescent conjugated oligothiophenes (LCOs), a unique class of amyloid dyes. When bound to amyloid, LCOs yield fluorescence emission spectra that reflect the 3D structure of the protein aggregates. Given that synthetic amyloid-beta peptide (A beta) has been shown to adopt distinct structural conformations with different biological activities, we asked whether A beta can assume structurally and functionally distinct conformations within the brain. To this end, we analyzed the LCO-stained cores of beta-amyloid plaques in postmortem tissue sections from frontal, temporal, and occipital neocortices in 40 cases of familial Alzheimers disease (AD) or sporadic (idiopathic) AD (sAD). The spectral attributes of LCO-bound plaques varied markedly in the brain, but the mean spectral properties of the amyloid cores were generally similar in all three cortical regions of individual patients. Remarkably, the LCO amyloid spectra differed significantly among some of the familial and sAD subtypes, and between typical patients with sAD and those with posterior cortical atrophy AD. Neither the amount of A beta nor its protease resistance correlated with LCO spectral properties. LCO spectral amyloid phenotypes could be partially conveyed to A beta plaques induced by experimental transmission in a mouse model. These findings indicate that polymorphic A beta-amyloid deposits within the brain cluster as clouds of conformational variants in different AD cases. Heterogeneity in the molecular architecture of pathogenic A beta among individuals and in etiologically distinct subtypes of AD justifies further studies to assess putative links between A beta conformation and clinical phenotype.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- Alzheimer; amyloid; neurodegeneration; prion; strains
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Rasmussen, Jay
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Mahler, Jasmin
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Beschorner, Nata ...
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Kaeser, Stephan ...
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Haesler, Lisa M.
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Baumann, Frank
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visa fler...
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Nyström, Sofie
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Portelius, Erik, ...
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Blennow, Kaj, 19 ...
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Lashley, Tammary ...
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Fox, Nick C.
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Sepulveda-Falla, ...
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Glatzel, Markus
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Oblak, Adrian L.
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Ghetti, Bernardi ...
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Nilsson, Peter
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Hammarström, Per
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Staufenbiel, Mat ...
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Walker, Lary C.
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Jucker, Mathias
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinsk biotek ...
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och Medicinsk biotek ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Neurovetenskaper
- Artiklar i publikationen
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Proceedings of t ...
- Av lärosätet
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Linköpings universitet
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Göteborgs universitet