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Sökning: onr:"swepub:oai:DiVA.org:liu-144024" > Clinical impact and...

  • Fabris, EnricoCardiology Department, Isala Heart Center, the Netherlands, Cardiovascular Department, University of Trieste, Italy (författare)

Clinical impact and predictors of complete ST segment resolution after primary percutaneous coronary intervention : A subanalysis of the ATLANTIC Trial

  • Artikel/kapitelEngelska2019

Förlag, utgivningsår, omfång ...

  • 2017-08-25
  • Sage Publications,2019
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:liu-144024
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-144024URI
  • https://doi.org/10.1177/2048872617727722DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding agencies: AstraZeneca
  • BACKGROUND: In the ATLANTIC (Administration of Ticagrelor in the catheterization laboratory or in the Ambulance for New ST elevation myocardial Infarction to open the Coronary artery) trial the early use of aspirin, anticoagulation, and ticagrelor coupled with very short medical contact-to-balloon times represent good indicators of optimal treatment of ST-elevation myocardial infarction and an ideal setting to explore which factors may influence coronary reperfusion beyond a well-established pre-hospital system.METHODS: This study sought to evaluate predictors of complete ST-segment resolution after percutaneous coronary intervention in ST-elevation myocardial infarction patients enrolled in the ATLANTIC trial. ST-segment analysis was performed on electrocardiograms recorded at the time of inclusion (pre-hospital electrocardiogram), and one hour after percutaneous coronary intervention (post-percutaneous coronary intervention electrocardiogram) by an independent core laboratory. Complete ST-segment resolution was defined as ≥70% ST-segment resolution.RESULTS: Complete ST-segment resolution occurred post-percutaneous coronary intervention in 54.9% ( n=800/1456) of patients and predicted lower 30-day composite major adverse cardiovascular and cerebrovascular events (odds ratio 0.35, 95% confidence interval 0.19-0.65; p<0.01), definite stent thrombosis (odds ratio 0.18, 95% confidence interval 0.02-0.88; p=0.03), and total mortality (odds ratio 0.43, 95% confidence interval 0.19-0.97; p=0.04). In multivariate analysis, independent negative predictors of complete ST-segment resolution were the time from symptoms to pre-hospital electrocardiogram (odds ratio 0.91, 95% confidence interval 0.85-0.98; p<0.01) and diabetes mellitus (odds ratio 0.6, 95% confidence interval 0.44-0.83; p<0.01); pre-hospital ticagrelor treatment showed a favorable trend for complete ST-segment resolution (odds ratio 1.22, 95% confidence interval 0.99-1.51; p=0.06).CONCLUSIONS: This study confirmed that post-percutaneous coronary intervention complete ST-segment resolution is a valid surrogate marker for cardiovascular clinical outcomes. In the current era of ST-elevation myocardial infarction reperfusion, patients' delay and diabetes mellitus are independent predictors of poor reperfusion and need specific attention in the future.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • van 't Hof, ArnoudIsala Heart Center, Maastricht University Medical Center, Zuyderland Hospital, the Netherlands (författare)
  • Hamm, Christian WKerckhoff Heart and Thorax Center, Germany (författare)
  • Lapostolle, FrédéricHôpital Avicenne, France (författare)
  • Lassen, Jens FAarhus University Hospital, Denmark (författare)
  • Goodman, Shaun GCanadian Heart Research Centre, University of Toronto, Canada (författare)
  • Ten Berg, Jurriën MSt Antonius Hospital Nieuwegein, the Netherlands (författare)
  • Bolognese, LeonardoCardiovascular and Neurological Department, Azienda Ospedaliera Arezzo, Italy (författare)
  • Cequier, AngelHeart Disease Institute, University of Barcelona, Spain (författare)
  • Chettibi, MohamedCentre Hospito-universitaire Frantz Fanon, Algeria (författare)
  • Hammett, Christopher JRoyal Brisbane and Women's Hospital, Australia (författare)
  • Huber, KurtWilhelminen Hospital, Austria, Sigmund Freud Private University, Austria (författare)
  • Janzon, MagnusLinköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US(Swepub:liu)magja75 (författare)
  • Merkely, BélaHeart and Vascular Center, Semmelweis University, Hungary (författare)
  • Storey, Robert FDepartment of Infection, Immunity and Cardiovascular Disease, University of Sheffield, UK (författare)
  • Zeymer, UweKlinikum Ludwigshafen and Institut für Herzinfarktforschung, Germany (författare)
  • Cantor, Warren JSouthlake Regional Health Centre, University of Toronto, Canada (författare)
  • Tsatsaris, AnneAstra Zeneca, UK (författare)
  • Kerneis, MathieuACTION Study Group, Sorbonne Université Paris 6, France (författare)
  • Diallo, AbdourahmaneACTION Study Group, Hospital Lariboisiere, France (författare)
  • Vicaut, EricACTION Study Group, Hospital Lariboisiere, France (författare)
  • Montalescot, GillesACTION Study Group, Sorbonne Université Paris 6, France (författare)
  • Cardiology Department, Isala Heart Center, the Netherlands, Cardiovascular Department, University of Trieste, ItalyIsala Heart Center, Maastricht University Medical Center, Zuyderland Hospital, the Netherlands (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:European Heart Journal: Sage Publications8:3, s. 208-2172048-87262048-8734

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