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Lymphocytes eject i...
Lymphocytes eject interferogenic mitochondrial DNA webs in response to CpG and non-CpG oligodeoxynucleotides of class C
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- Ingelsson, Björn, 1983- (author)
- Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten
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- Söderberg, Daniel, 1985- (author)
- Linköpings universitet,Avdelningen för läkemedelsforskning,Medicinska fakulteten
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- Strid, Tobias, 1982- (author)
- Linköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Medicinska fakulteten
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- Söderberg, Anita, 1949- (author)
- Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten
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- Bergh, Ann-Charlotte, 1980- (author)
- Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten
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- Loitto, Vesa-Matti, 1970- (author)
- Linköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Medicinska fakulteten
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- Lotfi, Kourosh, 1966- (author)
- Linköpings universitet,Avdelningen för läkemedelsforskning,Medicinska fakulteten,Region Östergötland, Hematologiska kliniken US
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- Segelmark, Mårten, 1957- (author)
- Linköpings universitet,Avdelningen för läkemedelsforskning,Medicinska fakulteten,Region Östergötland, Njurmedicinska kliniken US
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- Spyrou, Giannis, 1958- (author)
- Linköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Medicinska fakulteten
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- Rosén, Anders, 1948- (author)
- Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten
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(creator_code:org_t)
- 2018-01-02
- 2018
- English.
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In: Proceedings of the National Academy of Sciences of the United States of America. - Washington, DC, United States : National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 115:3, s. E478-E487
- Related links:
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https://liu.diva-por... (primary) (Raw object)
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https://www.pnas.org...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Circulating mitochondrial DNA (mtDNA) is receiving increasing attention as a danger-associated molecular pattern in conditions such as autoimmunity, cancer, and trauma. We report here that human lymphocytes [B cells, T cells, natural killer (NK) cells], monocytes, and neutrophils derived from healthy blood donors, as well as B cells from chronic lymphocytic leukemia patients, rapidly eject mtDNA as web filament structures upon recognition of CpG and non-CpG oligodeoxynucleotides of class C. The release was quenched by ZnCl2, independent of cell death (apoptosis, necrosis, necroptosis, autophagy), and continued in the presence of TLR9 signaling inhibitors. B-cell mtDNA webs were distinct from neutrophil extracellular traps concerning structure, reactive oxygen species (ROS) dependence, and were devoid of antibacterial proteins. mtDNA webs acted as rapid (within minutes) messengers, priming antiviral type I IFN production. In summary, our findings point at a previously unrecognized role for lymphocytes in antimicrobial defense, utilizing mtDNA webs as signals in synergy with cytokines and natural antibodies, and cast light on the interplay between mitochondria and the immune system.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Keyword
- CpG-C
- DAMP
- immune DNA sensing
- lymphocyte signaling
- mitochondrial DNA release
- Economic Information Systems
- Ekonomiska informationssystem
Publication and Content Type
- ref (subject category)
- art (subject category)
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Ingelsson, Björn ...
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Söderberg, Danie ...
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Strid, Tobias, 1 ...
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Söderberg, Anita ...
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Bergh, Ann-Charl ...
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Loitto, Vesa-Mat ...
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Lotfi, Kourosh, ...
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Segelmark, Mårte ...
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Spyrou, Giannis, ...
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Rosén, Anders, 1 ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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MEDICAL AND HEAL ...
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and Basic Medicine
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Linköping University