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Plasma S/R ratio of...
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Osman, AbdimajidÖstergötlands Läns Landsting,Linköpings universitet,Klinisk kemi,Hälsouniversitetet
(författare)
Plasma S/R ratio of warfarin co-varies with VKORC1 haplotype
- Artikel/kapitelEngelska2007
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Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:liu-14489
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-14489URI
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https://doi.org/10.1097/MBC.0b013e3280444bfdDOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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We recently reported that the low-dose VKORC1*2 haplotype is an important genetic determinant for warfarin dose requirement and is associated with difficulties to attain stable therapeutic prothrombin time-International Normalized Ratio in patients undergoing anticoagulation therapy. The aim of this study was to investigate whether patients with VKORC1*2 compared with patients carrying high-dose haplotypes VKORC1*3 or VKORC1*4 had different warfarin S/R ratios in their plasma, and whether that was related to CYP2C9 variants CYP2C9*2 and CYP2C9*3 or other factors. Samples from patients previously haplotyped for VKORC1 and measured for plasma warfarin concentration were genotyped for the CYP2C9 variants CYP2C9*2 and CYP2C9*3. Nonparametric statistical analysis was performed to elucidate whether there was any significant difference in the warfarin S/R ratio between the two patient groups. Our result shows that there is a significant difference (P < 0.01) in warfarin S/R ratios between VKORC1*2 and VKORC1*3 or VKORC1*4 patients. This difference did not originate from CYP2C9 variants CYP2C9*2 and CYP2C9*3. We speculate that VKORC1 haplotypes possibly are linked to some unidentified factors involved in the metabolic clearance of warfarin enantiomers. Dose-dependent variations in (S)-warfarin and (R)-warfarin clearance in these patients can also be a probable explanation for the difference in warfarin S/R ratios.
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Enström, CamillaLinköpings universitet,Institutionen för biomedicin och kirurgi,Hälsouniversitetet(Swepub:liu)camen30
(författare)
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Lindahl, TomasÖstergötlands Läns Landsting,Linköpings universitet,Klinisk kemi,Hälsouniversitetet(Swepub:liu)tomli13
(författare)
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Linköpings universitetKlinisk kemi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Blood Coagulation and Fibrinolysis18:3, s. 293-2960957-52351473-5733
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