Intermittent Access to Ethanol Induces Escalated Alcohol Consumption in Primates

Lindell, S. G.Laboratory of Comparative Behavioral Genomics, NIH/NIAAA/LNG, USA; Laboratory of Clinical and Translational Studies, National Institutes of Health/National Institute on Alcohol Abuse and Alcoholism, NIH Animal Center, USA (author)

Escalation of voluntary alcohol drinking is characteristic of alcohol addiction and can be induced in rodents using intermittent access to alcohol. This model has been used to evaluate candidate therapeutics, but key systems involved in the transition into alcohol addiction, such as CRF, differ in their organization between rodents and primates. We examined the ability of an intermittent access schedule to induce escalation of voluntary alcohol drinking in non-human primates and used this model to assess the role of corticotropin releasing hormone (CRF) signaling in this process.

Schwandt, M. L.Laboratory of Clinical and Translational Studies, National Institutes of Health/National Institute on Alcohol Abuse and Alcoholism, NIH Animal Center, USA (author)
Suomi, S. J.Laboratory of Comparative Ethology, National Institutes of Health/National Institute of Child Health and Human Development, NIH Animal Center, USA (author)
Rice, K. C.Chemical Biology Research Branch, National Institute on Drug Abuse, Bethesda, USA (author)
Heilig, Markus,1959-Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten,Region Östergötland, Psykiatriska kliniken,Laboratory of Clinical and Translational Studies, National Institutes of Health/National Institute on Alcohol Abuse and Alcoholism, NIH Animal Center, USA(Swepub:liu)marhe41 (author)
Barr, C. S.Laboratory of Comparative Behavioral Genomics, NIH/NIAAA/LNG, USA; Laboratory of Clinical and Translational Studies, National Institutes of Health/National Institute on Alcohol Abuse and Alcoholism, NIH Animal Center, USA (author)
Laboratory of Comparative Behavioral Genomics, NIH/NIAAA/LNG, USA; Laboratory of Clinical and Translational Studies, National Institutes of Health/National Institute on Alcohol Abuse and Alcoholism, NIH Animal Center, USALaboratory of Clinical and Translational Studies, National Institutes of Health/National Institute on Alcohol Abuse and Alcoholism, NIH Animal Center, USA (creator_code:org_t)

In:Journal of addictive behaviors, therapy and rehabilitation: SciTechnol6:12324-9005

By the author/editor: Lindell, S. G.; Schwandt, M. L.; Suomi, S. J.; Rice, K. C.; Heilig, Markus, ...; Barr, C. S.

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Health Sciences; and Substance Abuse

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