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Electronic Control ...
Electronic Control of Ca2+ Signalling in Neuronal Cells using an Organic Electronic Ion Pump
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- Isaksson, Joakim (author)
- Linköpings universitet,Institutionen för teknik och naturvetenskap,Tekniska högskolan
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- Kjäll, Peter (author)
- RISE,Karolinska Institutet,Acreo
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- Nilsson, David (author)
- Linköpings universitet,Institutionen för teknik och naturvetenskap,Tekniska högskolan
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- Robinson, Nathaniel (author)
- Linköpings universitet,Ytors Fysik och Kemi,Tekniska högskolan
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- Berggren, Magnus (author)
- Linköpings universitet,Institutionen för teknik och naturvetenskap,Tekniska högskolan
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- Richter-Dahlfors, Agneta (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2007-07-22
- 2007
- English.
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In: Nature Materials. - : Springer Science and Business Media LLC. - 1476-1122 .- 1476-4660. ; 6:9, s. 673-679
- Related links:
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http://urn.kb.se/res...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- Cells and tissues use finely regulated ion fluxes for their intra- and intercellular communication. Technologies providing spatial and temporal control for studies of such fluxes are however, limited. We have developed an electrophoretic ion pump made of poly(3,4-ethylenedioxythiophene) doped with poly(styrene sulphonate) (PEDOT:PSS) to mediate electronic control of the ion homeostasis in neurons. Ion delivery from a source reservoir to a receiving electrolyte via a PEDOT:PSS thin-film channel was achieved by electronic addressing. Ions are delivered in high quantities at an associated on/off ratio exceeding 300. This induces physiological signalling events that can be recorded at the single-cell level. Furthermore, miniaturization of the device to a 50-um-wide channel allows for stimulation of individual cells. As this technology platform allows for electronic control of ion signalling in individual cells with proper spatial and temporal resolution, it will be useful in further studies of communication in biological systems.
Subject headings
- NATURVETENSKAP -- Data- och informationsvetenskap (hsv//swe)
- NATURAL SCIENCES -- Computer and Information Sciences (hsv//eng)
Keyword
- TECHNOLOGY
- TEKNIKVETENSKAP
Publication and Content Type
- ref (subject category)
- art (subject category)
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