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  • Hombach-Klonisch, SabineUniv Manitoba, Canada (author)

Glioblastoma and chemoresistance to alkylating agents: Involvement of apoptosis, autophagy, and unfolded protein response

  • Article/chapterEnglish2018

Publisher, publication year, extent ...

  • PERGAMON-ELSEVIER SCIENCE LTD,2018
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:liu-147578
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-147578URI
  • https://doi.org/10.1016/j.pharmthera.2017.10.017DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:for swepub-publicationtype

Notes

  • Funding Agencies|Health Science Foundation [46602]; Mitacs [FR18469]; University Collaborative Research Program [47144]; Natural Sciences and Engineering Research Council of Canada (NSERC); Canada Foundation for Innovation (CFI); Cancer Research Society (CRS); Research Manitoba; Department of Surgery Research Fund
  • Despite advances in neurosurgical techniques and radio-/chemotherapy, the treatment of brain tumors remains a challenge. This is particularly true for the most frequent and fatal adult brain tumor, glioblastoma (GB). Upon diagnosis, the average survival time of GB patients remains only approximately 15 months. The alkylating drug temozolomide (TMZ) is routinely used in brain tumor patients and induces apoptosis, autophagy and unfolded protein response (UPR). Here, we review these cellular mechanisms and their contributions to TMZ chemoresistance in brain tumors, with a particular emphasis on TMZ chemoresistance in glioma stem cells and GB.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Mehrpour, MaryamCNRS, France; Univ Paris 05, France (author)
  • Shojaei, ShahlaUniv Manitoba, Canada; Isfahan Univ Med Sci, Iran (author)
  • Harlos, CraigUniv Manitoba, Canada; CancerCare Manitoba, Canada (author)
  • Pitz, MarshallUniv Manitoba, Canada; CancerCare Manitoba, Canada (author)
  • Hamai, AhmedCNRS, France; Univ Paris 05, France (author)
  • Siemianowicz, KrzysztofMed Univ Silesia, Poland (author)
  • Likus, WirginiaMed Univ Silesia, Poland (author)
  • Wiechec, EmiliaLinköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten(Swepub:liu)emiwi22 (author)
  • Toyota, Brian D.Univ British Columbia, Canada (author)
  • Hoshyar, ReyhaneBlrjand Univ Med Sci, Iran; Birjand Univ Med Sci, Iran (author)
  • Seyfoori, AmirUniv Victoria, Canada (author)
  • Sepehri, ZahraUniv Manitoba, Canada; Zabol Univ Med Sci, Iran (author)
  • Ande, Sudharsana R.Univ Manitoba, Canada (author)
  • Khadem, ForoughUniv Manitoba, Canada (author)
  • Akbari, MohsenUniv Victoria, Canada (author)
  • Gorman, Adrienne M.Natl Univ Ireland, Ireland; Natl Univ Ireland, Ireland (author)
  • Samali, AfshinNatl Univ Ireland, Ireland; Natl Univ Ireland, Ireland (author)
  • Klonisch, ThomasUniv Manitoba, Canada; CancerCare Manitoba, Canada (author)
  • Ghavami, SaeidUniv Manitoba, Canada; Shiraz Med Univ Med Sci, Iran (author)
  • Univ Manitoba, CanadaCNRS, France; Univ Paris 05, France (creator_code:org_t)

Related titles

  • In:Pharmacology and Therapeutics: PERGAMON-ELSEVIER SCIENCE LTD184, s. 13-410163-72581879-016X

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