A novel Schiff base derivative: Synthesis, two-photon absorption properties and application for bioimaging

• A novel donor-pi-acceptor-pi-donor type (D-pi-A-pi-D) Schiff base derivative (L) has been designed and synthesized. The structure of L is confirmed by single-crystal X-ray diffraction analysis as well. The photophysical properties of compound L were comprehensively investigated by using both experimental and theoretical methods. The results indicate that L exhibits large Stokes shift and moderate two-photon action (2PA) cross-section in the near infrared (NIR) region. Furthermore, the confocal microscopy imaging study demonstrates that compound L could penetrate into cells and target the cellular mitochondria compartment. Due to its low cytotoxicity, compound L provides a promising tool for directly lighting up the mitochondria compartment in living HepG2 cells. (C) 2018 Elsevier B.V. All rights reserved.

Subject headings

NATURVETENSKAP  -- Kemi -- Oorganisk kemi (hsv//swe)

NATURAL SCIENCES  -- Chemical Sciences -- Inorganic Chemistry (hsv//eng)

Keyword

Schiff base derivative; Two-photon absorption; Crystal structure; Bioimaging; Mitochondria

Publication and Content Type

ref (subject category)

art (subject category)