SwePub
Sök i LIBRIS databas

  Utökad sökning

L773:1545 7885
 

Sökning: L773:1545 7885 > Pharmacogenomic ide...

  • Azim, KasumBrain Research Institute, University of Zürich/ETHZ, Zürich, Switzerland / Adult Neurogenesis and Cellular Reprogramming, Institute of Physiological Chemistry, University Medical Centre of the Johannes Gutenberg University Mainz, Germany / Focus Program Translational Neuroscience, Johannes Gutenberg University Mainz, Germany (författare)

Pharmacogenomic identification of small molecules for lineage specific manipulation of subventricular zone germinal activity

  • Artikel/kapitelEngelska2017

Förlag, utgivningsår, omfång ...

  • 2017-03-28
  • San Francisco, United States :Public Library of Science,2017
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:liu-150032
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-150032URI
  • https://doi.org/10.1371/journal.pbio.2000698DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Strategies for promoting neural regeneration are hindered by the difficulty of manipulating desired neural fates in the brain without complex genetic methods. The subventricular zone (SVZ) is the largest germinal zone of the forebrain and is responsible for the lifelong generation of interneuron subtypes and oligodendrocytes. Here, we have performed a bioinformatics analysis of the transcriptome of dorsal and lateral SVZ in early postnatal mice, including neural stem cells (NSCs) and their immediate progenies, which generate distinct neural lineages. We identified multiple signaling pathways that trigger distinct downstream transcriptional networks to regulate the diversity of neural cells originating from the SVZ. Next, we used a novel in silico genomic analysis, searchable platform-independent expression database/connectivity map (SPIED/CMAP), to generate a catalogue of small molecules that can be used to manipulate SVZ microdomain-specific lineages. Finally, we demonstrate that compounds identified in this analysis promote the generation of specific cell lineages from NSCs in vivo, during postnatal life and adulthood, as well as in regenerative contexts. This study unravels new strategies for using small bioactive molecules to direct germinal activity in the SVZ, which has therapeutic potential in neurodegenerative diseases.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Angonin, DianeUniv Lyon, Université Claude Bernard Lyon 1, Inserm, Stem Cell and Brain Research Institute U1208, Bron, France (författare)
  • Marcy, GuillaumeUniv Lyon, Université Claude Bernard Lyon 1, Inserm, Stem Cell and Brain Research Institute U1208, Bron, France (författare)
  • Pieropan, FrancescaSchool of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, United Kingdom (författare)
  • Rivera, AndreaSchool of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, United Kingdom (författare)
  • Donega, VanessaUniv Lyon, Université Claude Bernard Lyon 1, Inserm, Stem Cell and Brain Research Institute U1208, Bron, France (författare)
  • Cantù, ClaudioIMLS, University of Zurich, Zurich, Switzerland(Swepub:liu)claca29 (författare)
  • Williams, GarethWolfson Centre for Age-Related Diseases, King's College London, Guy's Campus, London, United Kingdom (författare)
  • Berninger, BenediktAdult Neurogenesis and Cellular Reprogramming, Institute of Physiological Chemistry, University Medical Centre of the Johannes Gutenberg University Mainz, Germany / Focus Program Translational Neuroscience, Johannes Gutenberg University Mainz, Germany (författare)
  • Butt, Arthur MSchool of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, United Kingdom (författare)
  • Raineteau, OlivierBrain Research Institute, University of Zürich/ETHZ, Zürich, Switzerland / Univ Lyon, Université Claude Bernard Lyon 1, Inserm, Stem Cell and Brain Research Institute U1208, Bron, France (författare)
  • Brain Research Institute, University of Zürich/ETHZ, Zürich, Switzerland / Adult Neurogenesis and Cellular Reprogramming, Institute of Physiological Chemistry, University Medical Centre of the Johannes Gutenberg University Mainz, Germany / Focus Program Translational Neuroscience, Johannes Gutenberg University Mainz, GermanyUniv Lyon, Université Claude Bernard Lyon 1, Inserm, Stem Cell and Brain Research Institute U1208, Bron, France (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:PLoS biologySan Francisco, United States : Public Library of Science15:31544-91731545-7885

Internetlänk

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy