Persistent Wnt/β‐Catenin Signaling Determines Dorsalization of the Postnatal Subventricular Zone and Neural Stem Cell Specification into Oligodendrocytes and Glutamatergic Neurons

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Search: id:"swepub:oai:DiVA.org:liu-150042" > Persistent Wnt/β‐Ca...

1 of 1
Previous record
Next record
To hitlist

Details
MARC

Azim, KasumBrain Research Institute, University of Zürich/ETHZ, Zürich, Switzerland (author)

Persistent Wnt/β‐Catenin Signaling Determines Dorsalization of the Postnatal Subventricular Zone and Neural Stem Cell Specification into Oligodendrocytes and Glutamatergic Neurons

Article/chapterEnglish2014

Publisher, publication year, extent ...

2014-04-17
Durham, United States :AlphaMed Press, Inc.2014
printrdacarrier

Numbers

LIBRIS-ID:oai:DiVA.org:liu-150042
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-150042URI
https://doi.org/10.1002/stem.1639DOI

Supplementary language notes

Language:English
Summary in:English

Part of subdatabase

SwePubSwePub

Classification

Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

In the postnatal and adult central nervous system (CNS), the subventricular zone (SVZ) of the forebrain is the main source of neural stem cells (NSCs) that generate olfactory neurons and oligodendrocytes (OLs), the myelinating cells of the CNS. Here, we provide evidence of a primary role for canonical Wnt/β-catenin signaling in regulating NSC fate along neuronal and oligodendroglial lineages in the postnatal SVZ. Our findings demonstrate that glutamatergic neuronal precursors (NPs) and oligodendrocyte precursors (OPs) are derived strictly from the dorsal SVZ (dSVZ) microdomain under the control of Wnt/β-catenin, whereas GABAergic NPs are derived mainly from the lateral SVZ (lSVZ) microdomain independent of Wnt/β-catenin. Transcript analysis of microdissected SVZ microdomains revealed that canonical Wnt/β-catenin signaling was more pronounced in the dSVZ microdomain. This was confirmed using the β-catenin-activated Wnt-reporter mouse and by pharmacological stimulation of Wnt/β-catenin by infusion of the specific glycogen synthase kinase 3β inhibitor, AR-A014418, which profoundly increased the generation of cycling cells. In vivo genetic/pharmacological stimulation or inhibition of Wnt/β-catenin, respectively, increased and decreased the differentiation of dSVZ-NSCs into glutamatergic NPs, and had a converse effect on GABAergic NPs. Activation of Wnt/β-catenin dramatically stimulated the generation of OPs, but its inhibition had no effect, indicating other factors act in concert with Wnt/β-catenin to fine tune oligodendrogliogenesis in the postnatal dSVZ. These results demonstrate a role for Wnt/β-catenin signaling within the dorsal microdomain of the postnatal SVZ, in regulating the genesis of glutamatergic neurons and OLs.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Cell- och molekylärbiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Cell and Molecular Biology hsv//eng
Cell signaling
Nervous system
Neural induction
Neural stem cell
Neuron
Oligodendrocytes
Progenitor cells
Stem cell plasticity

Added entries (persons, corporate bodies, meetings, titles ...)

Fischer, BrunoBrain Research Institute, University of Zürich/ETHZ, Zürich, Switzerland (author)
Hurtado-Chong, AnahiBrain Research Institute, University of Zürich/ETHZ, Zürich, Switzerland (author)
Draganova, KalinaInstitute of Anatomy, University of Zürich, Switzerland (author)
Cantù, ClaudioInstitute of Molecular Life Sciences, University of Zürich, Switzerland(Swepub:liu)claca29 (author)
Zemke, MartinaInstitute of Anatomy, University of Zürich, Switzerland (author)
Sommer, LukasInstitute of Anatomy, University of Zürich, Switzerland (author)
Butt, ArthurInstitute of Biomedical and Biomolecular Sciences, School of Pharmacy and Biomedical Sciences, Portsmouth University, United Kingdom (author)
Raineteau, OlivierBrain Research Institute, University of Zürich/ETHZ, Zürich, Switzerland / Stem Cell and Brain Research Institute, INSERMU846, Lyon, France, Universite de Lyon,Universite Lyon, France (author)
Brain Research Institute, University of Zürich/ETHZ, Zürich, SwitzerlandInstitute of Anatomy, University of Zürich, Switzerland (creator_code:org_t)

Related titles

In:Stem CellsDurham, United States : AlphaMed Press, Inc.32:5, s. 1301-13121066-50991549-4918

Internet link

Find in a library

Stem Cells (Search for host publication in LIBRIS)

To the university's database

1 of 1
Previous record
Next record
To hitlist

Find more in SwePub

By the author/editor: Azim, Kasum; Fischer, Bruno; Hurtado-Chong, A ...; Draganova, Kalin ...; Cantù, Claudio; Zemke, Martina; show more...; Sommer, Lukas; Butt, Arthur; Raineteau, Olivi ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Cell and Molecul ...

Articles in the publication: Stem Cells

By the university: Linköping University

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se