High-performance, polymer-based direct cellular interfaces for electrical stimulation and recording

Due to the trade-off between their electrical/electrochemical performance and underwater stability, realizing polymer-based, high-performance direct cellular interfaces for electrical stimulation and recording has been very challenging. Herein, we developed transparent and conductive direct cellular interfaces based on a water-stable, high-performance poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS) film via solvent-assisted crystallization. The crystallized PEDOT:PSS on a polyethylene terephthalate (PET) substrate exhibited excellent electrical/electrochemical/optical characteristics, long-term underwater stability without film dissolution/delamination, and good viability for primarily cultured cardiomyocytes and neurons over several weeks. Furthermore, the highly crystallized, nanofibrillar PEDOT:PSS networks enabled dramatically enlarged surface areas and electrochemical activities, which were successfully employed to modulate cardiomyocyte beating via direct electrical stimulation. Finally, the high-performance PEDOT:PSS layer was seamlessly incorporated into transparent microelectrode arrays for efficient, real-time recording of cardiomyocyte action potentials with a high signal fidelity. All these results demonstrate the strong potential of crystallized PEDOT:PSS as a crucial component for a variety of versatile bioelectronic interfaces.

Kim, NaraGwangju Inst Sci and Technol, South Korea; Gwangju Inst Sci and Technol, South Korea; Gwangju Inst Sci and Technol, South Korea(Swepub:liu)narki16 (author)
Kim, YoungseokGwangju Inst Sci and Technol, South Korea; Univ Chicago, IL 60637 USA (author)
Baek, Min-SeoGwangju Inst Sci and Technol, South Korea (author)
Yoo, MinsuUniv Chicago, IL 60637 USA (author)
Kim, DongyoonGwangju Inst Sci and Technol, South Korea (author)
Lee, Won-JuneGwangju Inst Sci and Technol, South Korea (author)
Kang, Dong-HeeGwangju Inst Sci and Technol, South Korea (author)
Kim, SoheeDaegu Gyeongbuk Inst Sci and Technol, South Korea (author)
Lee, KwangheeGwangju Inst Sci and Technol, South Korea; Gwangju Inst Sci and Technol, South Korea; Gwangju Inst Sci and Technol, South Korea (author)
Yoon, Myung-HanGwangju Inst Sci and Technol, South Korea (author)
Gwangju Inst Sci and Technol, South KoreaGwangju Inst Sci and Technol, South Korea; Gwangju Inst Sci and Technol, South Korea; Gwangju Inst Sci and Technol, South Korea (creator_code:org_t)

By the author/editor: Kim, Seong-Min; Kim, Nara; Kim, Youngseok; Baek, Min-Seo; Yoo, Minsu; Kim, Dongyoon; show more...; Lee, Won-June; Kang, Dong-Hee; Kim, Sohee; Lee, Kwanghee; Yoon, Myung-Han; show less...

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