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  • Dzidic, MajdaLinköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,CSISP FISABIO, Spain; Inst Agrochem and Food Technol IATA CSIC, Spain,Department of Health and Genomics, Center for Advanced Research in Public Health, Valencia, Spain (författare)

Oral microbiome development during childhood: an ecological succession influenced by postnatal factors and associated with tooth decay

  • Artikel/kapitelEngelska2018

Förlag, utgivningsår, omfång ...

  • 2018-06-13
  • NATURE PUBLISHING GROUP,2018
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:liu-150853
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-150853URI
  • https://doi.org/10.1038/s41396-018-0204-zDOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-40931URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding Agencies|Spanish Ministry of Economy and Competitiveness [BIO2015-68711-R]; Research Council for the South-East Sweden [79001]; Swedish Research Council [2016-01698]; Swedish Heart and Lung Foundation [20140321]; Medical Research Council of Southeast Sweden [FORSS-573471]; Cancer and Allergy Foundation; European Research Council (ERC) [639226]
  • Information on how the oral microbiome develops during early childhood and how external factors influence this ecological process is scarce. We used high-throughput sequencing to characterize bacterial composition in saliva samples collected at 3, 6, 12, 24 months and 7 years of age in 90 longitudinally followed children, for whom clinical, dietary and health data were collected. Bacterial composition patterns changed through time, starting with "early colonizers", including Streptococcus and Veillonella; other bacterial genera such as Neisseria settled after 1 or 2 years of age. Dental caries development was associated with diverging microbial composition through time. Streptococcus cristatus appeared to be associated with increased risk of developing tooth decay and its role as potential biomarker of the disease should be studied with species-specific probes. Infants born by C-section had initially skewed bacterial content compared with vaginally delivered infants, but this was recovered with age. Shorter breastfeeding habits and antibiotic treatment during the first 2 years of age were associated with a distinct bacterial composition at later age. The findings presented describe oral microbiota development as an ecological succession where altered colonization pattern during the first year of life may have long-term consequences for childs oral and systemic health.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Collado, Maria C.Inst Agrochem and Food Technol IATA CSIC, Spain,Institute of Agrochemistry and Food Technology (IATA-CSIC), Department of Biotechnology, Unit of Lactic Acid Bacteria and Probiotics, Valencia, Spain,Department of Clinical and Experimental Medicine, Division of Autoimmunity and Immune Regulation, Linköping University, Linköping, Sweden (författare)
  • Abrahamsson, ThomasLinköpings universitet,Avdelningen för barns och kvinnors hälsa,Medicinska fakulteten,Region Östergötland, H.K.H. Kronprinsessan Victorias barn- och ungdomssjukhus,Department of Clinical and Experimental Medicine, Division of Pediatrics, Linköping University, Linköping, Sweden(Swepub:liu)thoab97 (författare)
  • Artacho, AlejandroCSISP FISABIO, Spain,Department of Health and Genomics, Center for Advanced Research in Public Health, Valencia, Spain (författare)
  • Stensson, MalinJönköping University,HHJ, Avdelningen för naturvetenskap och biomedicin,HHJ. Centrum för oral hälsa,HHJ. CHILD,HHJ. Biomedicinsk plattform,Jonkoping Univ, Sweden(Swepub:hj)stme (författare)
  • Jenmalm, MariaLinköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten(Swepub:liu)marje18 (författare)
  • Mira, AlexCSISP FISABIO, Spain,Department of Health and Genomics, Center for Advanced Research in Public Health, Valencia, Spain(Swepub:hj)mirale (författare)
  • Linköpings universitetAvdelningen för neuro- och inflammationsvetenskap (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:The ISME Journal: NATURE PUBLISHING GROUP12:9, s. 2292-23061751-73621751-7370

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