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Association studies...
Association studies on INS and IRS1polymorphisms: IRS1 G972R is associated with increased prostate cancer risk
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- Andersson, Patiyan, 1978- (författare)
- Linköpings universitet,Cellbiologi,Hälsouniversitetet
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- Varenhorst, Eberhard (författare)
- Linköpings universitet,Urologi,Hälsouniversitetet
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- Söderkvist, Peter (författare)
- Linköpings universitet,Cellbiologi,Hälsouniversitetet
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(creator_code:org_t)
- 2008
- 2008
- Engelska.
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Ingår i: Prostate Cancer and Prostatic Diseases. - 1365-7852 .- 1476-5608.
- Relaterad länk:
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http://urn.kb.se/res...
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Abstract
Ämnesord
Stäng
- We study the G972R polymorphism in the Insulin receptor substrate 1 gene (IRS1) and the +1127 PstI polymorphism of the Insulin gene (INS), in 120 and 151, respectively, incidentally discovered, histologically verified prostate cancers, and in 185 healthy control subjects. The number of IRS1 R allele was found to be significantly associated with increased risk of prostate cancer. Analysis of the INS +1127 PstI polymorphism shows no significant differences between cases and controls. We conclude that subjects carrying one or two R-alleles at the IRS1 G972R polymorphic site are at an elevated risk of developing prostate cancer.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- IRS1
- G972R
- INS
- Insulin
- prostate cancer
- Oncology
- Onkologi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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